Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Crystal arthritis

Calcium pyrophosphate deposition—nothing 'pseudo' about it!

Nature Reviews Rheumatology volume 7, pages 257–258 (2011)Cite this article

Subjects

Calcium pyrophosphate disease remains—50 years after its initial description—a challenging disease to diagnose and manage. Newly-reached consensus among European experts suggests standard nomenclature, some recommendations for diagnosis and treatment, and an ambitious future research agenda based on these decisions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. McCarty, D. J. Jr, Kohn, N. N. & Faires, J. S. The significance of calcium pyrophosphate crystals in the synovial fluid of arthritic patients: the “pseudogout syndrome”. I. Clinical aspects. Ann. Intern. Med. 56, 711–737 (1962).

    Article  CAS  Google Scholar 

  2. Žitňan, D. & Sit'Aj, Š. Chondrocalcinosis articularis. Section I. Clinical and radiological study. Ann. Rheum. Dis. 22, 142–152 (1963).

    Article  Google Scholar 

  3. Fuerst, M. et al. Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum. 60, 2694–2703 (2009).

    Article  CAS  Google Scholar 

  4. Zhang, W. et al. European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis. Ann. Rheum. Dis. 70, 563–570 (2011).

    Article  CAS  Google Scholar 

  5. Zhang, W. et al. EULAR recommendations for calcium pyrophosphate deposition. Part II: management. Ann. Rheum. Dis. 70, 571–575 (2011).

    Article  CAS  Google Scholar 

  6. Dieppe, P. & Swan, A. Identification of crystals in synovial fluid. Ann. Rheum. Dis. 58, 261–263 (1999).

    Article  CAS  Google Scholar 

  7. von Essen, R., Hölttä, A. M. & Pikkarainen, R. Quality control of synovial fluid crystal identification. Ann. Rheum. Dis. 57, 107–109 (1998).

    Article  CAS  Google Scholar 

  8. Das, S. K. et al. A randomized controlled trial to evaluate the slow-acting symptom modifying effects of a regimen containing colchicine in a subset of patients with osteoarthritis of the knee. Osteoarthritis Cartilage 10, 247–252 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rheumatology Section, CC-111W Zablocki VA Medical Center, 5000 W. National Avenue, Milwaukee, 53295, WI, USA

    Ann K. Rosenthal

  2. Division of Rheumatology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, 53226, WI, USA

    Lawrence M. Ryan

Authors
  1. Ann K. Rosenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lawrence M. Ryan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ann K. Rosenthal.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rosenthal, A., Ryan, L. Calcium pyrophosphate deposition—nothing 'pseudo' about it!. Nat Rev Rheumatol 7, 257–258 (2011). https://doi.org/10.1038/nrrheum.2011.50

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2011.50

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing