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Clathrin-mediated endocytosis before fluorescent proteins

Nature Reviews Molecular Cell Biology volume 7, pages 63–68 (2006)Cite this article

Abstract

The recent technological advance of using fluorescent proteins to image endocytic protein traffic has resulted in a greater understanding of this dynamic process. However, most of the main concepts for how clathrin-mediated endocytosis functions were formulated long before intrinsically fluorescent proteins were available. These important conceptual breakthroughs came from the clever interpretation of simple observations.

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Figure 1: The sequence of events in the endocytosis of yolk proteins by coated pits of mosquito oocytes.
Figure 2: An early proposal for a mechanism of receptor-mediated endocytosis.
Figure 3: An early proposal for a sorting endosome.

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Authors and Affiliations

  1. the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9038, Texas, USA

    Michael G. Roth

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  1. Michael G. Roth
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DATABASES

OMIM

hypercholesterolaemia

Swiss-Prot

AP50

(LDL)-receptor

Shibire

FURTHER INFORMATION

Michael Roth's laboratory

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Roth, M. Clathrin-mediated endocytosis before fluorescent proteins. Nat Rev Mol Cell Biol 7, 63–68 (2006). https://doi.org/10.1038/nrm1783

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