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Eph–ephrin promiscuity is now crystal clear

Nature Neuroscience volume 7, pages 417–418 (2004)Cite this article

The ephrin subclasses A and B are not thought to interact much with each other's receptors. A study in this issue now shows that ephrin-A5 can signal through the EphB2 receptor, toppling this dogma. The crystal structure of the EphB2–ephrin-A5 complex clarifies the molecular features of this interaction and suggests new hypotheses for the mechanism of ephrin receptor signaling.

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Figure 1: Binding interactions and sequence relationships of Eph receptors and ephrins.

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Authors and Affiliations

  1. Burnham Institute, La Jolla, 92037, USA, California

    Elena B Pasquale

  2. Department of Pathology, University of California at San Diego, La Jolla, 92093, California, USA

    Elena B Pasquale

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  1. Elena B Pasquale
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Pasquale, E. Eph–ephrin promiscuity is now crystal clear. Nat Neurosci 7, 417–418 (2004). https://doi.org/10.1038/nn0504-417

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