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Old player, new partner: EGFRvIII and cytokine receptor signaling in glioblastoma

Nature Neuroscience volume 19, pages 765–767 (2016)Cite this article

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The brain cancer glioblastoma relies on aberrant epidermal growth factor receptor (EGFRvIII) signaling for tumorigenesis. An essential co-receptor and feed-forward circuit maintain signaling in this deadly disease.

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Figure 1: OSMR is an obligate EGFRvIII co-receptor that defines a feed-forward mechanism with EGFRvIII and STAT3 in glioblastoma pathogenesis.

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Authors and Affiliations

  1. Genaro R. Villa and Paul S. Mischel are at the Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California, USA.,

    Genaro R Villa

  2. Genaro R. Villa is also in the Medical Scientist Training Program and Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.,

    Genaro R Villa

  3. Paul S. Mischel is also in the Department of Pathology and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.,

    Paul S Mischel

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  1. Genaro R Villa
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  2. Paul S Mischel
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Correspondence to Paul S Mischel.

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Villa, G., Mischel, P. Old player, new partner: EGFRvIII and cytokine receptor signaling in glioblastoma. Nat Neurosci 19, 765–767 (2016). https://doi.org/10.1038/nn.4302

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