Adult cells can be routinely reprogrammed into pluripotent stem cells by chemical and genetic means, such as the expression of a cocktail of exogenous transcription factors. It is now shown that growing cells on substrates with aligned features such as microgrooves can enhance this process.
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Xu, Y., Liu, L., Laslett, A. et al. Into the groove. Nature Mater 12, 1082–1084 (2013). https://doi.org/10.1038/nmat3821
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DOI: https://doi.org/10.1038/nmat3821
