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Iron metabolism meets signal transduction

Nature Genetics volume 38, pages 503–504 (2006)Cite this article

Mutations in hemojuvelin disrupt its ability to stimulate expression of the iron regulatory peptide hepcidin and result in the severe iron loading disorder juvenile hemochromatosis. A new study shows that hemojuvelin acts through the multifunctional bone morphogenetic protein pathway to modulate hepcidin levels, providing new insights into communication within a key physiological pathway.

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Figure 1: Hemojuvelin, a glycosylphosphatidylinositol (GPI)-linked membrane protein, acts as a BMP coreceptor and modulates hepcidin expression by stimulating BMP2 and BMP4 signaling.

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Authors and Affiliations

  1. Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, 4029, Queensland, Australia

    Gregory J Anderson & David M Frazer

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  1. Gregory J Anderson
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  2. David M Frazer
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Anderson, G., Frazer, D. Iron metabolism meets signal transduction. Nat Genet 38, 503–504 (2006). https://doi.org/10.1038/ng0506-503

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