Progerin, a mutated form of lamin A, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects.
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Meshorer, E., Gruenbaum, Y. NURD keeps chromatin young. Nat Cell Biol 11, 1176–1177 (2009). https://doi.org/10.1038/ncb1009-1176
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DOI: https://doi.org/10.1038/ncb1009-1176
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