New insight into the biology of biofilms is spawning novel commercial strategies for treating the intractable infections they cause.
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References
Donlan, R.M. Biofilm formation: a clinically relevant microbiological process. Clin. Infect. Dis. 33, 1387–1392 (2001).
Cook G., Costerton J.W., & Darouiche R.O. Direct confocal microscopy studies of the bacterial colonization in vitro of a silver-coated heart valve sewing cuff. Int. J. Antimicrob. Agents 13, 169–173 (2000).
Costerton, J.W., Geesey, G.G., & Cheng, K. How bacteria stick. Sci. Am. 238, 86–95 (1978).
Donlan, R.M. Biofilms: microbial life on surfaces. Emerg. Infect. Dis. 8, 881–890 (2002).
Kolenbrander, P.E. et al. Communication among oral bacteria. Microbiol. Mol. Biol. Rev. 66, 486–505 (2002).
Singh, P.K. et al. A component of innate immunity prevents bacterial biofilm development. Nature 417, 552–555 (2002).
Bachmann, S.P. et al. In vitro activity of caspofungin against Candida albicans biofilms. Antimicrob. Agents Chemother. 46, 3591–3596 (2002).
Hastings, J.W. & Nealson, K.H. Bacterial bioluminescence. Annu. Rev. Microbiol. 31, 549–495 (1977).
Eberhard A, et al. Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry 20, 2444–2449 (1981).
Engebrecht J. & Silverman, M. Identification of genes and gene products necessary for bacterial bioluminescence. Proc. Natl. Acad. Sci. USA 81, 4154–4158 (1984).
Fuqua, C. & Greenberg, E.P. Listening in on bacteria: acyl-homoserine lactone signaling. Nat. Rev. Mol. Cell Biol. 3, 685–695 (2002).
Li, Y.H. et al. A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation. J. Bacteriol. 184, 2699–2708 (2002).
Chen, X et al. Structural identification of a bacterial quorum-sensing signal containing boron. Nature 415, 545–549 (2002).
Yoon, S.S. et al. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev. Cell. 3, 593–603 (2002).
Davies, D. Understanding biofilm resistance to antibacterial agents. Nat. Rev. Drug Discov. 2, 114–122 (2003).
Stewart, P.S. & Costerton, J.W. Antibiotic resistance of bacteria in biofilms. Lancet 358, 135–138 (2001).
Drenkard, E. & Ausubel, F.M. Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 416, 740–743 (2002).
Rasmussen, K. Growth alert: US cleans up with bioremediation markets. Water Conditioning and Purification. 44, 71–72 (April, 2002).
Labrenz, M. Formation of sphalerite (ZnS) deposits in natural biofilms of sulfate-reducing bacteria. Science 290, 1744–1747 (2000).
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Schachter, B. Slimy business—the biotechnology of biofilms. Nat Biotechnol 21, 361–365 (2003). https://doi.org/10.1038/nbt0403-361
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DOI: https://doi.org/10.1038/nbt0403-361
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