Abstract
This retrospective study of 549 corneo-sclerai rim cultures shows that gentamicin, used in MK and K-Sol medium storage at 4°C, has decreased donor contamination from 43% in whole- globe storage to 13%, but failed to eliminate coagulase negative staphylococci (37%), streptococci (28%) and fungi (28%). Donor-to-host transmitted staphylococcal and streptococcal endophthalmitis have been reported previously. We present the first documented case of donor-to-recipient transmitted fungal endophthalmitis following corneal transplantation using corneas stored in MK or K-Sol solution at 4°C; Candida albicans was isolated. Recommendations are made to assess critically the true incidence of donor fungal contamination and the necessity of adding anti-mycotic agents to preservation medium for 4°C storage. In the absence of ideal antimicrobial cover for corneal preservation solutions, stringent prophylactic measures to reduce contamination and continued monitoring of corneo-sclerai rim cultures are warranted, if the poor visual consequences of donor-to-host transmitted endophthalmitis are to be avoided.
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Fong, L., Gladstone, D. & Casey, T. Corneo-scleral rim cultures: Donor contamination a case of fungal endophthalmitis transmitted by K-Sol stored cornea. Eye 2, 670–676 (1988). https://doi.org/10.1038/eye.1988.123
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DOI: https://doi.org/10.1038/eye.1988.123
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