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Conditioning Regimens

Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants

Bone Marrow Transplantation volume 41, pages 851–859 (2008)Cite this article

Abstract

We analysed the outcome and hospitalization requirements of the first 100 patients (Hodgkin's disease (HD), N=13; multiple myeloma (MM), N=14; CLL, N=12; non-Hodgkin's lymphoma (NHL), N=17; myelodysplastic syndrome (MDS), N=18; AML, N=24 and CML, N=2) treated in Denmark with haematopoietic cell transplantation after non-myeloablative conditioning with TBI 2 Gy±fludarabine. The cumulative incidence of acute GVHD grade II–IV and extensive chronic GVHD was 67 and 49%. After a median follow-up of 534 days, the overall survival, PFS, relapse-related mortality and treatment-related mortality were 59, 50, 25 and 17%, respectively. Patients with CLL, NHL, AML and MDS with <5% blasts at any time had a favourable outcome with a PFS of 61–71%. Patients with MM, HD and MDS and a history of ⩾5% blasts had a less favourable outcome with a PFS of 19–38% (P=0.001). The cumulative incidence of discontinuation of immunosuppression was 37%. During the first and second year post transplant, patients experienced a mean of 41 and 13 outpatient clinic visits, and 53 and 16 days of hospitalization. Sixteen patients were admitted to the intensive care unit, of whom eight are still alive. In conclusion, transplantation outcomes were encouraging, but complications requiring admission and outpatient clinic visits occur frequently post transplant.

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Acknowledgements

We thank the medical, nursing and laboratory staff of the participating departments for their contribution to this study. We also thank Mrs Anne Bjørlig for excellent technical assistance. This study was supported with grants from the Danish Medical Research Council, Novo Nordisk Research Foundation, Benzon Foundation, Danish Cancer Society, Lundbeck Foundation and Rigshospitalet. BK is a Rigshospitalet research fellow.

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Authors and Affiliations

  1. Department of Haematology, Allogeneic Haematopoietic Cell Transplantation Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    B Kornblit, T Masmas, S L Petersen & L Vindeløv

  2. Department of Clinical Immunology, Tissue Typing Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    B Kornblit, H O Madsen, L P Ryder, A Svejgaard & B Jakobsen

  3. Department of Haematology, Bone Marrow Transplantation Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    H Sengeløv, G Olesen & L Vindeløv

  4. Paediatric Clinic II, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    C Heilmann

  5. Department of Clinical Immunology, Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    E Dickmeiss

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  1. B Kornblit
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Correspondence to B Kornblit.

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Kornblit, B., Masmas, T., Madsen, H. et al. Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants. Bone Marrow Transplant 41, 851–859 (2008). https://doi.org/10.1038/bmt.2008.10

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