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A neural pathway for itch

A class of spinothalamic tract neurons is selectively excited by stimuli that cause itch, suggesting that this sensation is mediated by distinct peripheral and central pathways.

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Figure 1: Schematic view of central processing of painful and pruritic stimuli.

References

  1. Greaves, M. W. & Wall, P. D. in Dermatology in General Medicine (ed. Freedberg, I. M.) 487–494 (McGraw-Hill, New York, 1998).

    Google Scholar 

  2. McMahon, S. B. & Koltzenburg, M. Trends Neurosci. 15, 497–501 (1992).

    Article  CAS  Google Scholar 

  3. Andrew, D. & Craig, A. D. Nat. Neurosci. 4, 72–77 (2001).

    Article  CAS  Google Scholar 

  4. Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H. O. & Torebjörk, H. E. J. Neurosci. 17, 8003–8008 (1997).

    Article  CAS  Google Scholar 

  5. Jinks, S. L. & Carstens, E. J. Neurophysiol. 84, 616–627 (2000).

    Article  CAS  Google Scholar 

  6. Nilsson, H. J., Levinsson, A. & Schouenborg, J. Pain 71, 49–55 (1997).

    Article  CAS  Google Scholar 

  7. Brull, S. J., Atanassoff, P. G., Silverman, D. G., Zhang, J. & LaMotte, R. H. Somatosens. Mot. Res. 16, 299–303 (1999).

    Article  CAS  Google Scholar 

  8. Atanassoff, P. G. et al. Somatosens. Mot. Res. 16, 291–298 (1999).

    Article  CAS  Google Scholar 

  9. Ballantyne, J. C., Loach, A. B. & Carr, D. B. Pain 33, 149–160 (1988).

    Article  CAS  Google Scholar 

  10. Kumeta, Y. et al. Anesthesiology 69, 371–376 (1988).

    Article  CAS  Google Scholar 

  11. Jones, E. A. & Bergasa, N. V. Hepatology 29, 1003–1006 (1999).

    Article  CAS  Google Scholar 

  12. Metze, D., Reimann, S. & Luger, T. A. Ann. NY Acad. Sci. 885, 430–432 (1999).

    Article  CAS  Google Scholar 

  13. Bickford, R. G. L. Clin. Sci. 3, 377–386 (1938).

    Google Scholar 

Download references

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Schmelz, M. A neural pathway for itch. Nat Neurosci 4, 9–10 (2001). https://doi.org/10.1038/82956

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