Abstract
It has recently been suggested that polymorphisms in the human apolipoprotein A-I (apo A-I) gene locus may be related to the development of premature atherosclerosis1 and hypertriglyceridaemia2. To understand if and how these polymorphisms affect apo A-I gene expression, we studied the genomic sequences flanking the apo A-I gene. Here we show the presence of another apolipoprotein gene, apolipoprotein C-III (apo C-III), approximately 2.6 kilobases (kb) downstream of the 3′ end of the apo A-I gene. We also show that the apo A-I and apo C-III genes are convergently transcribed and that a polymorphism previously reported to be associated with hypertriglyceridaemia2 may be due to a single base pair substitution in the 3′-noncoding region of apo C-III mRNA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Karathanasis, S. K., Norum, R. A., Zannis, V. I. & Breslow, J. L. Nature 301, 718–720 (1983).
Rees, A., Shoulders, C. C., Stocks, J., Galton, D. J. & Baralle, F. E. Lancet i, 444–446 (1983).
Barker, W. C. & Dayhoff, M. O. Comp. Biochem. Physiol. 57 B, 309–315 (1977).
Karathanasis, S. K., Zannis, V. I. & Breslow, J. L. Nature (submitted).
Woods, D. E., Markham, A. F., Ricker, A. T., Goldberger, G. & Colten, H. R. Proc. natn. Acad. Sci. U.S.A. 79, 5661–5665 (1982).
Brewer, H. B., Shulman, R., Herbert, P. & Ronan, R. J. biol. Chem. 249, 4975–4984 (1974).
Shulman, R. S., Herbert, P. N., Frederickson, D. S., Wehrly, K. & Brewer, H. B. J. biol. Chem. 249, 4969–4974 (1974).
Karathanasis, S. K., Zannis, V. I. & Breslow, J. L. Proc. natn. Acad. Sci. U.S.A. (in the press).
Norum, R. A. et al. New Engl. J. Med. 306, 1513–1519 (1982).
Zannis, V. I. & Breslow, J. L. in Electrophoresis 1979 (ed. Radola, B. J.) 437–473 (de Gruyter, New York, 1980).
Herbert, P. N., Assmann, G., Gotto, A. M. Jr & Fredrickson, D. S. in The Metabolic Basis of Inherited Disease (eds Stanbury, J. B., Wyngaarden, J. B., Fredrickson, D. S., Goldstein, J. L. & Brown, M. S.) 589–651 (McGraw-Hill, New York, 1982).
Huff, M. W., Fidge, N. H., Nestel, P. J., Billington, T. & Watson, B. J. Lipid Res. 22, 1235–1246 (1981).
Schonfeld, G., Genge, P. K., Miller, J., Reilly, P. & Witzum, J. Metabolism 28, 1001–1010 (1979).
Havel, R. J., Shore, V. G., Shore, B. & Bier, D. M., Circulation Res. 27, 595–600 (1970).
Brown, W. V. & Baginsky, M. L. Biochem. biophys. Res. Commun. 46, 375–382 (1972).
Kinnunen, P. K. J. & Ehnholm, C. FEBS Lett. 65, 354–357 (1976).
Windier, E., Chao, Y. & Havel, R. J. J. biol. Chem. 255, 5475–5480 (1980).
Shelburne, F., Hanks, J., Meyers, W. & Quarfordt, S. J. clin. Invest. 65, 652–658 (1980).
Windler, E., Chao, Y. & Havel, R. J. J. biol. Chem. 255, 8303–8307 (1980).
Carlson, L. A. & Ballantyne, D. Atherosclerosis 23, 563–568 (1976).
Catapano, A. L. Atherosclerosis 35, 419–424 (1980).
Naruszewicz, M., Szostak, W. B., Cybulska, B., Kozlowska, M. & Chotkowska, E. Atherosclerosis 35, 383–392 (1980).
Kashyap, M. L., Hynd, B. A., Robinson, K. & Gartside, P. S. Metabolism 30, 111–118 (1981).
Lambert, D. et al. J. Lab. clin. Med. 97, 834–841 (1981).
Breslow, J. L. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6861–6865 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Karathanasis, S., McPherson, J., Zannis, V. et al. Linkage of human apolipoproteins A-I and C-III genes. Nature 304, 371–373 (1983). https://doi.org/10.1038/304371a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/304371a0
This article is cited by
-
Synergic effects of the ApoC3 and ApoA4 polymorphisms on the risk of hypertension
Genes & Genomics (2017)
-
Influences of −482C>T and 3238G>C polymorphisms of the Apolipoprotein C3 gene on prevalence of metabolic syndrome
Genes & Genomics (2016)
-
Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?
Current Atherosclerosis Reports (2016)
-
Utility of genetic determinants of lipids and cardiovascular events in assessing risk
Nature Reviews Cardiology (2011)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
