Abstract
IT has been shown in mice that specific immunological unresponsiveness to contact sensitisation with picryl chloride induced by pretreatment with picryl sulphonic acid is a positive phenomenon rather than an absence of specific immunocompetent cells1. In this system it was shown that transfer of lymph node cells from unresponsive to normal mice would limit the recipients' contact sensitivity response to picryl chloride and that these cells had characteristics suggesting that they were T as opposed to B cells2. We should like to report that a similar state of unresponsiveness to the dinitrophenyl group in guinea pigs can be broken by treatment with cyclophosphamide (CY) just before sensitisation and this is associated with the return of the ability of T cells to proliferate in the draining lymph node as part of the immune response.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Asherson, G. L., Zembala, M., and Barnes, R. M. R., Clin. exp. Immun., 9, 111 (1971).
Zembala, M., and Asherson, G. L., Nature, 244, 227 (1973).
Frey, J. R., de Weck, A. L., and Geleick, H., J. invest. Derm., 42, 41 (1964).
Polak, L., Frey, J. R., and Turk, J. L., Immunology, 25, 451 (1973).
Turk, J. L., Parker, D., and Poulter, L. W., Immunology, 23, 493 (1972).
Turk, J. L., and Parker, D., Immunology, 24, 751 (1973).
Katz, S. I., Parker, D., Sommer, G., and Turk, J. L., Nature, 248, 612 (1974).
Turk, J. L., and Poulter, L. W., Clin. exp. Immun., 10, 285 (1972).
Poulter, L. W., and Turk, J. L., Nature new Biol., 238, 17 (1972).
Turk, J. L., and Poulter, L. W., Int. Arch. Allergy, 43, 620 (1972).
Polak, L., Geleick, H., and Frey, J. R., Monogr. Allergy, 8, 168 (1974).
Mäkelä, O., and Nossal, G. Z. V., J. Immun., 88, 613 (1962).
Hraba, T., Monogr. Allergy, 3, 66 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLAK, L., TURK, J. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity. Nature 249, 654–656 (1974). https://doi.org/10.1038/249654a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249654a0
This article is cited by
-
The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy
Cancer Chemotherapy and Pharmacology (2016)
-
Concomitant combination of active immunotherapy and carboplatin- or paclitaxel-based chemotherapy improves anti-tumor response
Cancer Immunology, Immunotherapy (2013)
-
Combined therapy with cyclophosphamide and DNA preparation inhibits the tumor growth in mice
Genetic Vaccines and Therapy (2009)
-
Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy
Cancer Immunology, Immunotherapy (2009)
-
Chemotherapy Enhances CD8+ T Cell-mediated Antitumor Immunity Induced by Vaccination With Vaccinia Virus
Molecular Therapy (2007)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
