Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

The Significance of Glycosylated Proteins

Nature volume 236, pages 147–151 (1972)Cite this article

Abstract

It has been suggested that glycosylation is a means of labelling proteins for intracellular recognition and export. This hypothesis is rejected in favour of the idea that the attached carbohydrate determines the extracellular fate of the protein molecule.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Spiro, R. G., Ann. Rev. Biochem., 39, 599 (1970).

    Article  CAS  PubMed  Google Scholar 

  2. Marshall, R. D., and Neuberger, A., Adv. Carbohydrate Chem. Biochem., 25, 407 (1970).

    Article  CAS  Google Scholar 

  3. Spiro, R. G., New Engl. J. Med., 281, 991 (1969).

    Article  CAS  PubMed  Google Scholar 

  4. Eylar, E. H., J. Theoret. Biol., 10, 89 (1966).

    Article  CAS  Google Scholar 

  5. Williams, C. A., and Ganoza, M. C., in Plasma Protein Metabolism (edit. by Rothschild, M. A., and Waldman, T.) (Academic Press, New York, 1970).

    Google Scholar 

  6. Redman, C. M., Siekevitz, P., and Palade, G. E., J. Biol. Chem., 241, 1150 (1966).

    CAS  PubMed  Google Scholar 

  7. Gaye, P., and Denamur, R., Biochem. Biophys. Res. Commun., 41, 226 (1970).

    Article  Google Scholar 

  8. Palmiter, R. D., Oka, T., and Schimke, R. T., J. Biol. Chem., 246, 724 (1971).

    CAS  PubMed  Google Scholar 

  9. Schubert, D., and Cohn, M., J. Mol. Biol., 38, 273 (1968).

    Article  CAS  PubMed  Google Scholar 

  10. Blobel, G., and Sabatini, D. D., J. Cell Biol., 45, 130 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hallinan, T., Murty, C. N., and Grant, T. H., Arch. Biochem. Biophys., 125, 715 (1968).

    Article  CAS  PubMed  Google Scholar 

  12. Schenkein, I., and Uhr, J. W., J. Cell Biol., 46, 42 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Baker, J. R., and Roden, L., Fed. Proc., 29, 338 (1970).

    Google Scholar 

  14. Jackson, R. L., and Hirs, C. H. W., J. Biol. Chem., 245, 624 (1970).

    CAS  PubMed  Google Scholar 

  15. Schimizu, A., Putnam, F. W., Paul, C., Clamp, J. R., and Johnson, I., Nature New Biology, 231, 73 (1971).

    Article  Google Scholar 

  16. Roseman, S., Chem. Phys. Lipids, 5, 270 (1970).

    Article  CAS  PubMed  Google Scholar 

  17. Schachter, H., Jabbal, I., Hudgin, R. L., Pinteric, L., McGuire, E. J., and Roseman, S., J. Biol. Chem., 245, 1090 (1970).

    CAS  PubMed  Google Scholar 

  18. Zegury, D., Uhr, J. W., Jamieson, J. D., and Palade, G. E., J. Cell Biol., 46, 52 (1970).

    Article  Google Scholar 

  19. Melchers, F., Behringwerk-Mitt., 49, 169 (1969).

    CAS  Google Scholar 

  20. Choi, Y. S., Knopf, P. M., and Lennox, E. S., Biochemistry, 10, 659 (1971).

    Article  CAS  PubMed  Google Scholar 

  21. Rambourg, A., Hernandez, W., and Leblond, C. P., J. Cell Biol., 40, 395 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Peters, T., Fleischer, B., and Fleischer, S., J. Biol. Chem., 246, 240 (1971).

    CAS  PubMed  Google Scholar 

  23. Kawasaki, T., and Yamashina, I., J. Biochem., Tokyo, 68, 689 (1970).

    Article  CAS  Google Scholar 

  24. Kawasaki, T., and Yamashina, I., Biochim. Biophys. Acta, 225, 234 (1971).

    Article  CAS  PubMed  Google Scholar 

  25. Bosmann, H. B., Life Sci., 8, 737 (1969).

    Article  CAS  PubMed  Google Scholar 

  26. Winterburn, P. J., and Phelps, C. F., Biochem. J., 121, 711 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Tetas, M., Chao, H., and Molnar, J., Arch. Biochem. Biophys., 138, 135 (1970).

    Article  CAS  PubMed  Google Scholar 

  28. Wolstenholm, G. E. W., and O'Connor, M.(eds), Exocrine Pancreas (Ciba Foundation Symposium, Churchill, London, 1962).

  29. Plummer, T. H., and Hirs, C. H. W., J. Biol. Chem., 239, 2530 (1964).

    CAS  PubMed  Google Scholar 

  30. Catley, B. J., Moore, S., and Stein, W. H., J. Biol. Chem., 244, 933 (1969).

    CAS  PubMed  Google Scholar 

  31. Jenness, R., in Milk Proteins, 1 (edit. by McKenzie, H. A.) (Academic Press, New York, 1970).

    Google Scholar 

  32. Fevold, H. L., Adv. Protein Chem., 6, 187 (1951).

    Article  CAS  PubMed  Google Scholar 

  33. Montgomery, R., in The Carbohydrates, 2B (edit. by Pigman, W., and Horton, D.) (Academic Press, New York, 1970).

    Google Scholar 

  34. Barman, T. E., Biochim. Biophys. Acta, 214, 242 (1970).

    Article  CAS  PubMed  Google Scholar 

  35. Winzler, R. J., in Modern Problems in Pediatrics 10, Part II Fourth Intern. Cystic Fibrosis Symp. (edit. by Rossi, E., and Stoll, E.) (Karger, Basle, 1967).

    Google Scholar 

  36. Schultze, H. E., and Heremans, J. F., in Molecular Biology of Human Proteins, 1 (Elsevier, Amsterdam, 1966).

    Google Scholar 

  37. Rothschild, M. A., and Waldman, T.(eds.), in Plasma Protein Metabolism, (Academic Press, New York, 1970).

  38. Peterson, P. A., J. Biol. Chem., 246, 34 (1971).

    CAS  PubMed  Google Scholar 

  39. Nakane, P. K., J. Histochem. Cytochem., 18, 9 (1970).

    Article  CAS  PubMed  Google Scholar 

  40. Li, C. H., Dixon, J. S., Lo, T. B., Schmidt, K. D., and Pankov, Y. A., Arch. Biochem. Biophys., 141, 705 (1970).

    Article  CAS  PubMed  Google Scholar 

  41. Sox, H., Fed. Proc., 29, 703 (1970).

    Google Scholar 

  42. Spiro, R. G., Lucas, F., and Rudall, K. M., Nature New Biology, 231, 54 (1971).

    Article  CAS  PubMed  Google Scholar 

  43. Grant, M. E., Steven, F. S., Jackson, D. S., and Sandberg, L. B., Biochem. J., 121, 197 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Goldstone, A., and Koenig, H., Life Sci., 9, 1341 (1970).

    Article  CAS  Google Scholar 

  45. Miyajima, N., Tomikawa, M., Kawasaki, T., and Yamashina, I., J. Biochem. Tokyo, 66, 711 (1969).

    CAS  PubMed  Google Scholar 

  46. Kornfeld, R., Kornfeld, S., J. Biol. Chem., 245, 2536 (1970).

    CAS  PubMed  Google Scholar 

  47. Pepper, D. S., and Jamieson, G. A., Biochemistry, 9, 3706 (1970).

    Article  CAS  PubMed  Google Scholar 

  48. Szewczuk, A., and Connell, G. E., Biochim. Biophys. Acta, 83, 218 (1964).

    CAS  PubMed  Google Scholar 

  49. Bossa, F., John, R. A., Borra, D., and Fasella, P., FEBS Lett., 2, 115 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. De Bernard, B., Pugliarello, M. C., Sandri, G., Sottocasa, G. L., and Vittur, F., FEBS Lett., 12, 125 (1971).

    Article  CAS  PubMed  Google Scholar 

  51. Martin, S. S., and Bosmann, H. B., Biochim. Biophys. Acta, 230, 411 (1971).

    Article  CAS  PubMed  Google Scholar 

  52. Martin, S. S., and Bosmann, H. B., Exp. Cell Res., 66, 59 (1971).

    Article  PubMed  Google Scholar 

  53. Kashnig, D. M., and Kasper, C. B., J. Biol. Chem., 244, 3786 (1969).

    CAS  PubMed  Google Scholar 

  54. Sinohara, H., Asano, Y., and Fukui, A., Biochim. Biophys. Acta, 237, 273 (1971).

    Article  CAS  Google Scholar 

  55. Bradshaw, R. A., Ericsson, L. H., and Walsh, K. A., Proc. US Nat. Acad. Sci., 63, 1389 (1969).

    Article  ADS  CAS  Google Scholar 

  56. Brew, K., Castellino, F. J., Vanaman, T. C., and Hill, R. L., J. Biol. Chem., 245, 4570 (1970).

    CAS  PubMed  Google Scholar 

  57. Adelson, J. W., Nature, 229, 321 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  58. Berry, S. A., Johnson, K. G., and Campbell, J. N., Biochim. Biophys. Acta, 220, 269 (1970).

    Article  CAS  PubMed  Google Scholar 

  59. Skaug, K., and Christensen, T. B., Biochim. Biophys. Acta, 230, 627 (1971).

    Article  CAS  PubMed  Google Scholar 

  60. Pazur, J. H., Knull, K. R., and Simpson, D. L., Biochem. Biophys. Res. Commun., 40, 110 (1970).

    Article  CAS  PubMed  Google Scholar 

  61. Lee, T., and Hager, L. P., Fed. Proc., 29, 599 (1970).

    Google Scholar 

  62. Blumberg, B. S., and Warren, L., Biochim. Biophys. Acta, 50, 90 (1961).

    Article  CAS  Google Scholar 

  63. Muldoon, T. G., and Westphal, U., J. Biol. Chem., 242, 5636 (1967).

    CAS  PubMed  Google Scholar 

  64. Schmid, K., and Kamiyama, S., Biochemistry, 2, 271 (1963).

    Article  CAS  PubMed  Google Scholar 

  65. Oshiro, Y., and Eylar, E. H., Arch. Biochem. Biophys., 130, 227 (1969).

    Article  CAS  PubMed  Google Scholar 

  66. Suttajit, M., Reichert, L. E., and Winzler, R. J., J. Biol. Chem., 246, 3405 (1971).

    CAS  PubMed  Google Scholar 

  67. Van Hall, E. V., Vaitukaitis, J. L., Ross, G. T., Hickman, J. W., and Ashwell, G., Endocrinology, 88, 456 (1971).

    Article  CAS  PubMed  Google Scholar 

  68. Morgan, W. T. J., in Modern Problems in Paediatrics 10 (edit. by Rossi, E., and Stoll, E.) (Fourth Intern. Cystic Fibrosis Symp., Karger, Basle, 1967).

    Google Scholar 

  69. Mester, L., in Fibrinogen (edit. by Laki, K.) (Arnold, London, 1968).

    Google Scholar 

  70. Morgan, P. H., Jacobs, H. G., Segrest, J. P., and Cunningham, L. W., J. Biol. Chem., 245, 5042 (1970).

    CAS  PubMed  Google Scholar 

  71. Morell, A. G., Gregoriadis, G., Scheinberg, H., Hickman, J., and Ashwell, G., J. Biol. Chem., 246, 1461 (1971).

    CAS  PubMed  Google Scholar 

  72. Schauer, R., and Faillard, H., Z. Physiol. Chem., 349, 961 (1968).

    Article  CAS  Google Scholar 

  73. Winzler, R. J., Intern. Rev. Cytol., 29, 77 (1970).

    Article  CAS  Google Scholar 

  74. Amos, D. B., Fed. Proc., 29, 2018 (1970).

    CAS  PubMed  Google Scholar 

  75. Losick, R., and Robbins, P. W., J. Mol. Biol., 30, 445 (1967).

    Article  CAS  PubMed  Google Scholar 

  76. Wu, H. C., Meezan, E., Black, P. H., and Robbins, P. W., Bio chemistry, 8, 2509 (1969).

    CAS  Google Scholar 

  77. Bosmann, H. B., Biochem. Biophys. Res. Commun., 43, 1118 (1971).

    Article  CAS  PubMed  Google Scholar 

  78. Cleland, R. L., Biopolymers, 9, 811 (1970).

    Article  CAS  PubMed  Google Scholar 

  79. Sundararajan, P. R., and Rao, V. S. R., Biopolymers, 9, 1239 (1970).

    Article  CAS  Google Scholar 

  80. Greer, J., Kaufman, H. W., and Kalb, A. J., J. Mol. Biol., 48, 365 (1970).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University College, Cathays Park, Cardiff, CF1 1XL

    P. J. WINTERBURN

  2. Department of Biochemistry, The Medical School, University Walk, Bristol, BS8 1TD

    C. F. PHELPS

Authors
  1. P. J. WINTERBURN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. F. PHELPS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WINTERBURN, P., PHELPS, C. The Significance of Glycosylated Proteins. Nature 236, 147–151 (1972). https://doi.org/10.1038/236147a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/236147a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing