Abstract
The simple pattern of variability in mouse lambda chains suggests that diversity is generated by somatic spontaneous mutation and by sequential selection by antigen of single step mutants.
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References
Hood, L., Gray, W. R., Sanders, B. G., and Dreyer, W. J., Cold Spring Harb. Symp. Quant. Biol., 32, 133 (1967).
Hobbs, J. R., Brit. J. Cancer, 22, 717 (1968).
Appella, E., McIntire, K. R., and Perham, R. N., J. Mol. Biol., 27, 391 (1967).
Appella, E., and Perham, R. N., J. Mol. Biol., 33, 963 (1968).
Wu, T. T., and Kabat, E., J. Exp. Med., 132, 211 (1970).
Hood, L., and Talmage, D. W., Science, 168, 325 (1970).
Hood, L., McKean, D., and Potter, M., Science (in the press).
Schubert, D., and Horibata, K., J. Mol. Biol., 38, 263 (1968).
Potter, M., Meth. Cancer Res., 2, 105 (1967).
Abel, C. A., and Grey, H. M., Biochemistry, 7, 2682 (1968).
Raftery, M. A., and Cole, R. D., Biochem. Biophys. Res. Commun., 10, 467 (1963).
Hirs, C. H. W., J. Biol. Chem., 219, 611 (1956).
Weigert, M. G., and Garen, A., J. Mol. Biol., 12, 488 (1965).
Matsubara, H., and Lasaki, R. M., Biochem. Biophys. Res. Commun., 35, 175 (1969).
Konigsberg, W., and Hill, R. J., J. Biol. Chem., 237, 8, 2547 (1962).
Yamada, S., and Itano, H. A., Biochim. Biophys. Acta, 130, 538 (1966).
Mazur, R. H., Ellis, B. W., and Cammarata, P. S., J. Biol. Chem., 237, 1619 (1962).
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WEIGERT, M., CESARI, I., YONKOVICH, S. et al. Variability in the Lambda Light Chain Sequences of Mouse Antibody. Nature 228, 1045–1047 (1970). https://doi.org/10.1038/2281045a0
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DOI: https://doi.org/10.1038/2281045a0
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