Abstract
ACCORDING to the cyclol theory of the structure of proteins1—a working hypothesis recently put forward in these columns—the polypeptide, the essential unit in the molecule on the classical theory, is replaced by the cyclized polypeptide (Fig. 1): correspondingly the classical peptide links (joining one pair of C,N atoms) are replaced either by the double peptide links (joining two pairs of C,N atoms) or by the triple peptide link (joining three pairs of C,N atoms) (Fig. 2). The reaction polypeptides &rlharr; proteins is thus regarded as a ring chain tautomerism2, which takes the form if the appropriate groups are in the imide form, and the form if they are in the amide form.
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References
D. M. Wrinch, NATURE, 137, 411 1936.
See, for example, J. W. Baker, ” Tautomerism” (1934), p. 38.
The figures of Pauling and Sherman given in J. Chem. Phys., 1, 606 (1933), calculated on the basis of the value of 208 kilogram calories for the heat of dissociation of N2, have been modified to take account of the revised value of 169 kilogram calories (see Mulliken, Phys. Rev., 46, 144 (1934); Herzberg and Sponer, Z. phys. Chem., B, 26, 1, though this modification is without effect on these calculations.
J. Biol. Chem., 109, 325, 329 (1935).
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WRINCH, D. Energy of Formation of Cyclol Molecules. Nature 138, 241–242 (1936). https://doi.org/10.1038/138241a0
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DOI: https://doi.org/10.1038/138241a0
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