Abstract
For biomedical applications drug carrying polymers are coated around magnetic iron oxide particles to form microspheres. In the present study, the iron oxide powder was ball milled. Microspheres were then synthesized by solvent evaporation, resulting in iron oxide particles encapsulated in a polymer and drug coating. Various parameters, such as the duration of milling and agitation speed as well as the polymer concentration were varied. A milling time of 72 h was found to yield a small size and narrow size distribution of particles; the average particle size was about 600 nm. Measurements of the change in grain size and the magnetic properties of the powder with milling time were performed. It was determined that the size of the microspheres was not sensitive to the initial particle size, but it could be decreased by variation of agitation speed or polymer concentration. The agitation speed and polymer concentration of 400 rpm and 0.04 g poly(l-lactic acid) in 8 g dicholoromethane, respectively, was found to yield small, spherical microspheres with a narrow size distribution. The surface morphology and magnetic properties of the microspheres was also analyzed.
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References
A. Kuznetsov, O. A. Harutyunyan, E. Dobrinski, V. Filippov, A. Malenkov and A. Vanin, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997) p. 379.
A. Lübbe, A. Christoph and C. Bergemann, J. Surg. Res. 95 (2001) 200.
A. Lübbe and A. S. Bergemann, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997) p. 457.
A. Wilfried and H. Nowak, in “Magnetism in Medicine” (Wiley, 1998).
B. Hertzog, T. Mottl, D. Yim and E. Mathiowitz, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997) p. 78.
I. Ŝafarîk and M. Ŝafaríková, Monatsh. Chem. 133 (2002) 737.
S. Davis, Trends Biotechnol. 15 (1997) 217.
J. Davda, S. De, W. Zhou and V. Labhasetwar, in “Biomedical Polymers and Polymer Therapeutics”, edited by E. Chiellihi, J. Sunamoto, C. Migliweresi, R. M. Ottenbrite and D. Cohn (Kluwer, New York, 2001).
U. Häfeli, G. Pauer, W. Roberts, J. Humm and R. Macklis, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997) p. 501.
D. Jiles, in “Introduction to Magnetism and Magnetic Materials” (Chapman & Hall, New York, 1990).
D. K. Kim, Y. Zhang, W. Voit, K. V. Rao, J. Kehr, B. Bjelke and M. Muhammed, Scripta Mater. 44 (2001) 1713.
D. Müller-Schulte, Frank Füssl and M. Cuyper, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997), p. 93.
W. Saltzman, in “Drug Delivery: Engineering Principles for Drug Therapy” (Oxford, 2001).
M. Mchenry and D. Laughlin, Acta Mater. 48 (2000) 223.
C. C. Koch, in “Materials Science and Technology: A Comprehensive Treatment”, vol. 15, edited by R. Cahn, P. Haasen and E. Kramer (Wiley-VCH, Weinheim, 1991) p. 193.
T. W. Chung, Y. Y. Huang, Y. L. Tsai and Y. Z. Liu, J. Microencapsul. 19 (2002) 463.
Y. Zhao, H. Sheng and K. Lu, Acta Mater. 49 (2001) 365.
J. Ugelstad, A. Berge and T. Ellingsen, Prog. Polym. Sci. 17 (1992) 87.
J. Ugelstad, P. Stenstad and L. Kilaas, Blood Purif. 11 (1993) 349.
W. S. Prestvik, A. Berge, P. C. Mork, P. Stenstad and J. Ugelstad, in “Clinical Applications of Magnetic Carriers”, edited by U. Häfeli, W. Schütt, J. Teller and M. Zborowski (Plenum Press, New York, 1997) p. 11.
S. Rudge, C. Peterson, C. Vessely, J. Koda, S. Stevens and L. Catterall, J. Contr. Release 74 (2001) 335.
B. D. Cullity and S. Stock, in “Elements of X-Ray Diffraction” (Prentice Hall, New York, 2001).
H. Klung and L. Alexander, in “X-ray Diffraction Procedures for Polycrystalline and Amorphous Materials” (Wiley, New York, 1974).
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Ramanujan, R.V., Chong, W.T. The synthesis and characterization of polymer coated iron oxide microspheres. Journal of Materials Science: Materials in Medicine 15, 901–908 (2004). https://doi.org/10.1023/B:JMSM.0000036278.09272.97
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DOI: https://doi.org/10.1023/B:JMSM.0000036278.09272.97