Abstract
Apatite cement (AC) can be injected through syringe and forms apatite mass. Therefore, AC is very useful for a minimally invasive surgical operation aimed for the reconstruction of bone defects. However, injectability of current AC is not satisfactory for its clinical use. In this investigation, therefore, spherical tetracalcium phosphate (s-TTCP) was prepared with plasma melting method and its effect on injectability were evaluated as well as other basic properties of AC. We found much better handling property and injectability when we used s-TTCP as a component of AC (s-AC). For example, cement spread area used as an index of consistency of the s-AC paste was 512 mm2 whereas that of ordinary AC with irregular TTCP (i-AC) was 158 mm2 when powder to liquid mixing ratio was 2.5. However, diametral tensile strength of set s-AC (1.4 MPa) was significantly lower than that of set i-AC (10.7 MPa) when the powder to liquid ratio was 4.0. X-ray powder diffraction analysis revealed limited formation of apatite in the case of s-AC. Although there are some drawbacks, we feel the use of spherical particle is very useful to improve the injectability of AC. Therefore, it is important to find suitable method to prepare spherical powder as the component of AC.
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References
W. E. Brow and L. C. Chow, Paste as Mineralizers and Cements, U.S. Patent, No. 4 612 053 (1986).
W. E. Brow and L. C. Chow, in “Cements Research Progress”, edited by P. W. Brown (American Ceramic Society, Westerville, OH, 1987) pp. 351-379.
B. R. Constantz, I. C. Ison, M. T. Fulmer, R. D. Poser, S. T. Smith, M. Vanwagoner, J. Ross, S. A. Goldstein, J. B. Jupiter and D. I. Rosentalr, Science 267 (1995) 1796.
F. C. M. Driessens, M. G. Boltong, O. Bermudez and J. A. Planell, J. Mater Sci.: Mater. Med. 4 (1993) 503.
F. C. M. Driessens, M. G. Boltong, O. Bermudez, J. A. Planell, M. P. Ginebra and E. Fernandez, ibid. 5 (1994) 164.
R. I. Martin and P. W. Brown, ibid. 6 (1995) 138.
K. Kurashina, H. Kurita, M. Hirano, J. M. A. De Blieck, C. P. A. T. Kleink and K. De Groot, ibid. 6 (1995) 340.
K. Ishikawai, S. Takagi, L. C. Chow and Y. Ishikawa, ibid. 6 (1995) 528.
K. Ishikawa, Y. Miyamoto, M. Kon, M. Nagayama and K. Asaoka, Biomaterials 16 (1995) 527.
K. Ishikawa and K. Asaoka, J. Biomed. Mater. Res. 29 (1995) 1537.
K. Ishikawa, Y. Miyamoto, M. Takechi, Y. Ueyama, K. Suzuki, M. Nagayama and T. Matsumur, ibid. 44 (1999) 322.
P. D. Constantino, C. D. Friedman, K. Jones, L. C. Chow, H. J. Pelzer and G. A. Sisson, Arch. Otolaryngol. Head Neck Surg. 117 (1991) 379.
C. D. Friedman, P. D. Constantino, K. Jones, L. C. Chow, H. J. Pelzer and G. A. Sisson, ibid. 117 (1991) 385.
Y. Miyamoto, K. Ishikawa, M. Takechi, T. Toh, Y. Yoshida, M. Nagayama, M. Kon and K. Asaoka, J. Biomed. Mater. Res. 37 (1997) 457.
Y. Miyamoto, K. Ishikawa, M. Takechi, M. Yuasa, M. Kon, M. Nagayama and K. Asaoka, Biomaterials 17 (1996) 1429.
Y. Ueyama, K. Ishikawa, T. Mano, T. Koyama, T. Matsumura and K. Suzuki, J. Biomed. Mater. Res. 55 (2001) 652.
G. Pasquire, B. Glautre, M. C. Blary, K. Anselme and P. Hardouin, J. Mater. Sci.: Mater. Med. 7 (1996) 683.
G. Daculsi, Biomaterials 19 (1998) 1473.
A. Dupraz, T. P. Nguyen, M. Richard, J. Delecrin and G. Duculsi, ibid. 7 (1996) 52.
L. Leroux, Z. Hatim, M. Freche and J. L. Lacout, Bone 25 (1999) 31S.
P. Iooss, A.-M. Le Ray, G. Grimandi, G. Daculsi and C. Merle, Biomaterials 22 (2001) 2785.
M. P. Ginebra, A. Rilliard, E. Fernandez, C. Elvira, J. San Roman and J. A. Planell, J. Biomed. Mater. Res. 57 (2001) 113.
S. Sarda, E. Fernandez, M. Nilsson, M. Balcells and J. A. Planell, ibid. 61 (2002) 653.
K. Yamashita, in “Funtai” (Kyoritsu Press, Tokyo, 1981) pp. 220-264.
Y. Miyamoto, K. Ishikawa, H. Fukao, M. Sawada, M. Nagayama, M. Kon and K. Asaoka, Biomaterials 16 (1995) 855.
M. Takechi, Y. Miyamoto, Y. Ishikawa, M. Yuasa, M. Nagayama, M. Kon and K. Asaoka, J. Mater. Sci. Mater. Med. 7 (1996) 317.
Y. Miyamoto, K. Ishikawa, M. Takechi, T. Toh, T. Yuasa, M. Nagayama and K. Suzuki, Biomaterials 19 (1998) 707.
K. Ishikawa, Y. Miyamoto, M. Takechi, T. Toh, M. Kon, M. Nagayama and K. Asaoka, J. Biomed. Mater. Res. 36 (1997) 393.
Y. Momota, Y. Miyamoto, K. Ishikawa, M. Takechi, T. Yuasa, S. Tatehara, M. Nagayama and K. Suzuki, J. Biomed. Mater. Res. 7 (2002) 542.
M. Adachi, T. Goto, N. Wakamatsu, H. Kamemizu, M. Iijima, S.-H. Kim and Y. Doi, J. Gifu. Dent. Soc. 29 (2003) 223.
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Ishikawa, K., Matsuya, S., Nakagawa, M. et al. Basic properties of apatite cement containing spherical tetracalcium phosphate made with plasma melting method. Journal of Materials Science: Materials in Medicine 15, 13–17 (2004). https://doi.org/10.1023/B:JMSM.0000010092.01661.a8
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DOI: https://doi.org/10.1023/B:JMSM.0000010092.01661.a8