Skip to main content
SpringerLink
Log in

CASE REPORT: K-ras Mutation and Loss of Heterozygosity at 17p with β-Catenin Accumulation in Intramucosal Carcinoma of the Ileostomy in Familial Adenomatous Polyposis: A Case Report

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Burt RW, Berenson MM, Lee RG, Tolman KG, Freston JW, Gardner EJ: Upper gastrointestinal polyps in Gardner's syndrome. Gastroenterology 86:295-301, 1984

    Google Scholar 

  2. Roth JA, Logio T: Carcinoma arising in an ileostomy stoma: An unusual complication of adenomatous polyposis coli. Cancer 49:2180-2184, 1982

    Google Scholar 

  3. Ross DS, Bussing R, Dietrich J: Carcinoma arising in an ileostomy. IMJ III Med J 172:163-166, 1987

    Google Scholar 

  4. Primrose JN, Quirke P, Johnston D: Carcinoma of the ileostomy in a patient with familial adenomatous polyposis. Br J Surg 75:384, 1988

    Google Scholar 

  5. Suarez V, Alexander-Williams J, O'Connor HJ: Campos A, Fuggle WJ, Thompson H, Enker WE, Greenstein AJ: Carcinoma developing in ileostomies after 25 or more years. Gastroenterology 95:205-208, 1988

    Google Scholar 

  6. Gilson TP, Sollenberger LL: Adenocarcinoma of an ileostomy in a patient with familial adenomatous polyposis. Report of a case. Dis Colon Rectum 35:261-265, 1992

    Google Scholar 

  7. Johnson JA 3rd, Talton DS, Poole GV: Adenocarcinoma of a Brooke ileostomy for adenomatous polyposis coli. Am J Gastroenterol 88:1122-1124, 1993

    Google Scholar 

  8. Mimura T, Kuramoto S, Yamasaki K, Kaminishi M: Familial adenomatous polyposis: a case report and histologic mucin study. J Clin Gastroenterol 28:372-376, 1999

    Google Scholar 

  9. Herring JA, Hall CC, Johnson JA, Poole GV, Subramony C, Suvarna-Gurram V, Hall TJ: K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient. Am J Gastroenterol 91:587-591, 1996

    Google Scholar 

  10. Yamagata S, Muto T, Uchida Y, Masaki T, Higuchi Y, Sawada T, Hirooka T: Polypoid growth and K-ras codon 12 mutation in colorectal cancer. Cancer 75:953-957, 1995

    Google Scholar 

  11. Kanazawa T, Watanabe T, Kazama S, Tada T, Koketsu S, Nagawa H: Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. Int J Cancer 102:225-229, 2002

    Google Scholar 

  12. Hamilton SR, Bussey HJ, Mendelsohn G, Diamond MP, Pavlides G, Hutcheon D, Harbison M, Shermeta D, Morson BC, Yardley JH: Ileal adenomas after colectomy in nine patients with adenomatous polyposis coli/Gardner's syndrome. Gastroenterology 77:1252-1257, 1979

    Google Scholar 

  13. Bertario L, Russo A, Sala P, Varesco L, Giarola M, Mondini P, Pierotti M, Spinelli P, Radice P: Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis. J Clin Oncol 21:1698-1707, 2003

    Google Scholar 

  14. Wu JS, Paul P, McGannon EA, Church JM: APC genotype, polyp number, and surgical options in familial adenomatous polyposis. Ann Surg 227:57-62, 1998

    Google Scholar 

  15. Crabtree MD, Tomlinson IP, Hodgson SV, Neale K, Phillips RK, Houlston RS: Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes. Gut 51:420-423, 2002

    Google Scholar 

  16. Bjork J, Akerbrant H, Iselius L, Bergman A, Engwall Y, Wahlstrom J, Martinsson T, Nordling M, Hultcrantz R: Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations. Gastroenterology 121:1127-1135, 2001

    Google Scholar 

  17. Friedl W, Meuschel S, Caspari R, Lamberti C, Krieger S, Sengteller M, Propping P: Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. Hum Genet 97:579-584, 1996

    Google Scholar 

  18. Cetta F, Olschwang S, Petracci M, Montalto G, Baldi C, Zuckermann M, Costantini RM, Fusco A: Genetic alterations in thyroid carcinoma associated with familial adenomatous polyposis: clinical implications and suggestions for early detection. World J Surg 22:1231-1236, 1998

    Google Scholar 

  19. Giardiello FM, Petersen GM, Piantadosi S, Gruber SB, Traboulsi EI, Offerhaus GJ, Muro K, Krush AJ, Booker SV, Luce MC, Laken SJ, Kinzler KW, Vogelstein B, Hamilton SR: APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis. Gut 40:521-525, 1997

    Google Scholar 

  20. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature 359:235-237, 1992

    Google Scholar 

  21. Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP: Refining the relation between ‘first hits’ and ‘second hits’ at the APC locus: the ‘loose fit’ model and evidence for differences in somatic mutation spectra among patients. Oncogene 22:4257-4265, 2003

    Google Scholar 

  22. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK, Hamilton S, Vogelstein B: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717-7722, 1990

    Google Scholar 

  23. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL: Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532, 1988

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Surgical Oncology, University of Tokyo, Tokyo, Japan

    Keisuke Hata, Toshiaki Watanabe, Yutaka J. Kawamura, Hironori Ishigami, Takamitsu Kanazawa, Tomohiro Tada, Bin Zhao, Shinichiro Koketsu & Hirokazu Nagawa

Authors
  1. Keisuke Hata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshiaki Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yutaka J. Kawamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hironori Ishigami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takamitsu Kanazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tomohiro Tada
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bin Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shinichiro Koketsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hirokazu Nagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Keisuke Hata.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hata, K., Watanabe, T., Kawamura, Y.J. et al. CASE REPORT: K-ras Mutation and Loss of Heterozygosity at 17p with β-Catenin Accumulation in Intramucosal Carcinoma of the Ileostomy in Familial Adenomatous Polyposis: A Case Report. Dig Dis Sci 48, 2310–2314 (2003). https://doi.org/10.1023/B:DDAS.0000007868.52339.22

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:DDAS.0000007868.52339.22

Search

Navigation