Abstract
We propose a method of evaluation of anticlimacteric efficiency of a drug by its effect on the estrous cycle. The study was carried out on 9-month-old mice with retained, but notably reduced reproductive function. Analysis of the cell components of the estrous cycle was carried out on histological preparations of vaginal smears.
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REFERENCES
From Modern Fundamental Biology to New Scientifically-Based Technologies [in Russian], Pushchino (2001).
Manual of Experimental (Preclinical) Studies of New Phar-macological Substances [in Russian], Moscow (2000).
Y. Gao and R. V. Short, J. Reprod. Fertil., 101, No. 2, 477–481 (1994).
H. V. Ratajczak, P. T. Thomas, J. Gerhart, and R. B. Sothern, In Vivo, 9, No. 4, 299–304 (1995).
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Goldshtein, D.V., Vikhlyantseva, E.V., Sakharova, N.K. et al. Histological Method for Evaluation of the Efficiency of Enerlit-Clima. Bulletin of Experimental Biology and Medicine 138, 205–206 (2004). https://doi.org/10.1023/B:BEBM.0000048390.58193.2a
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DOI: https://doi.org/10.1023/B:BEBM.0000048390.58193.2a