Abstract
We studied expression of dystrophin in skeletal muscles of C57BL/10J-mdx mice after transplantation of human embryonic and fetal myoblasts and bone marrow stromal cells. Dystrophin-positive areas corresponding to the location of transplanted cell were detected in muscles of all recipient mice after transplantation of different cell cultures, but the distribution of dystrophin characteristic of normal muscle fibers was detected only after transplantation of embryonic myoblasts. Dystrophin distribution in muscle fibers after transplantation of fetal myoblasts and bone marrow stromal cells was atypical.
Similar content being viewed by others
REFERENCES
G. Ferrari and F. Mavillo, Neuromuscul. Disord., 12, Suppl. 1, 7–10 (2002).
E. Lagasse, H. Connors, M. Al-Dhalimy, et al., Nat. Med., 6, 1229–1234 (2000).
T. Partridge, Q. L. Lu, G. Morris, and E. Hoffman, Ibid., 4, 1208–1209 (1998).
B. E. Strauer, M. Brehm, T. Zeus, et al., Circulation, 106, 1913–1918 (2002).
J. D. White, J. J. Bower, J. B. Kurek, and L. Austin, Muscle Nerve, 24, 695–697 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saburina, I.N., Semenova, M.L., Gol'dshtein, D.V. et al. Transplantation of Human Embryonic Myoblasts and Bone Marrow Stromal Cells into Skeletal Muscle of C57BL/10J-mdx Mice. Bulletin of Experimental Biology and Medicine 137, 521–524 (2004). https://doi.org/10.1023/B:BEBM.0000038169.17529.ac
Issue Date:
DOI: https://doi.org/10.1023/B:BEBM.0000038169.17529.ac