Skip to main content
SpringerLink
Log in

Examination of Tissue Distribution of Helicobacter pylori Within Columnar-Lined Esophagus

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

H. pylori may colonize columnar-lined esophagus,although an etiologic role in esophageal adenocarcinomais unproven. H. pylori can adhere to intestinalmetaplasia in the stomach. This study was designed to examine if H. pylori adheres to specializedintestinal metaplasia in columnar-lined esophagus.Esophageal biopsies from patients with columnar-linedesophagus were reviewed. Patients with only gastric metaplasia were excluded. Sections withspecialized intestinal metaplasia in at least one thirdof at least one gland were recut, stained using theGiemsa stain, and reexamined by two independentpathologists using strict criteria for adherence by H.pylori . The 209 esophageal biopsies with adequatespecialized intestinal metaplasia from 58 patients wereexamined: H. pylori was only seen on gastric metaplasia in three patients — and never onspecialized intestinal metaplasia. Within the esophagus,H. pylori adheres only to gastric metaplasia, which isnot considered premalignant for esophagealadenocarcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Sharma VK, Chockalingam H, Hornung CA, Vasudeva R, Howden CW: Changing trends in esophageal cancer: A 15-year experience in a single center. Am J Gastroenterol 93:702–705, 1998

    Google Scholar 

  2. Sharma VK, Hornung CA, Vasudeva R, Howden CW: Changing trends in esophageal cancer at a VA hospital. Gastroenterology 112:A286, 1997 (abstract)

    Google Scholar 

  3. Yang PC, Davis S: Incidence of cancer of the esophagus in the US by histologic type. Cancer 61:612–617, 1988

    Google Scholar 

  4. Pera M, Cameron AJ, Trastek VF, Carpenter HA, Zinsmeister AR: Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 104:510–513, 1993

    Google Scholar 

  5. Blot WJ, Devesa SS, Kneller RW, Fraumeni JF: Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 265:1287–1289, 1991

    Google Scholar 

  6. Moyana TN, Janoski M: Recent trends in the epidemiology of esophageal cancer. Ann Clin Lab Sci 26:480–486, 1996

    Google Scholar 

  7. Zheng T, Mayne ST, Holford TR, Boyle P, Liu W, Chen Y, Mador M, Flannery J: Time and age-pe riod-cohort effects on incidence of esophageal cancer in Connecticut 1935-89. Cancer Cause Control 3:481–492, 1992

    Google Scholar 

  8. Macfarlane GJ, Boyle P: The epidemiology of oesophageal cancer in the UK and other European countries. J R Soc Med 87:334–337, 1994

    Google Scholar 

  9. Johnston BJ, Reed PI, Kaski C, Levi S: Rising incidence of oesophage al adenocarcinoma: A 20 year retrospective review from a single unit. Gut 40( suppl 1):A37, 1997 (abstract)

    Google Scholar 

  10. Spechler SJ, Goyal RK: The columnar lined esophagus, intestinal metaplasia, and norman Barrett. Gastroenterology 110:614–621, 1996

    Google Scholar 

  11. Prach AT, MacDonald TM, Hopwood D, Johnston DA: Increasing incidence of Barrett's oesophagus: diagnostic zeal or genuine observation? Gut 40( suppl 1):A36, 1997 (abstract)

    Google Scholar 

  12. Sharma P, Morales TG, Bhattacharyya A, Garewal HS, Sampliner RE: Increasing prevalence of short sequent Barrett's esophagus (SSBE). Am J Gastroenterol 92:1603, 1997 (abstract)

    Google Scholar 

  13. Sharma VK, Taillon D, Burns RG, Vasudeva R, Howden CW, Demian SE: Is Helicobacter pylori associated with adenocarcinoma of the esophagus? Gastroenterology 112:A653, 1997 (abstract)

    Google Scholar 

  14. Vicari J, Falk GW, Richter JE: Helicobacter pylori and acid peptic diseases of the esophagus: is it conce ivable? Am J Gastroenterol 92:1097–1102, 1997

    Google Scholar 

  15. Talley NJ, Cameron AJ, Shorter RG, Zinsmeister AR, Phillips SF: Campylobacter pylori and Barrett's esophagus. Mayo Clin Proc 63:1176–1180, 1988

    Google Scholar 

  16. Paull G, Yardley JH: Gastric and esophageal Campylobacter pylori in patients with Barrett's esophagus. Gastroenterology 95:216–218, 1988

    Google Scholar 

  17. Houck JA, Lucas JG: Absence of Campylobacter-like organisms in Barrett's esophagus. Arch Pathol Lab Med 113:470–472, 1989

    Google Scholar 

  18. Fallinborg J, Agnholt J, Moller-Petersen J, Christensen LA, Lomborg S, Sondergaard G, Teglbjaerg PS, Rasmussen SN: Campylobacter pylori in esophagus. Dig Dis Sci 34:1802–1803, 1989 (letter)

    Google Scholar 

  19. Walker SJ, Birch PJ, Stewart M, Stoddard CJ, Hart CA, Day DW: Patterns of colonisation of Campylobacter pylori in the oesophagus, stomach and duodenum. Gut 30:1334–1338, 1989

    Google Scholar 

  20. Gruppo Operative Per Lo Studio De lle Pre cancerosi Esofagee (GOSPE): Helicobacter pylori in Barrett's esophagus. Histopathology 18:568–570, 1991

    Google Scholar 

  21. Newton M, Bryan R, Burnham WR, Kamm MA: Evaluation of Helicobacter pylori in reflux oesophagitis and Barret's oesophagus. Gut 40:9–13, 1997

    Google Scholar 

  22. Csendes A, Smok G, Cerda G, Burdiles P, Mazza D, Csendes P: Prevalence of Helicobacter pylori infection in 190 control subjects and 236 patients with gastroesophage al reflux, erosive esophagitis or Barrett's esophagus. Dis Esophagus 10:38–42, 1997

    Google Scholar 

  23. Ricaurte O, Flejou JF, Vissuzaine C, Goldfain D, Rotenberg A, Cadiot G, Potet F: Helicobacter pylori infection in patients with Barrett's esophagus: A prospective immunohistochemical study. J Clin Pathol 49:176–177, 1996

    Google Scholar 

  24. Abbas Z, Hussainy AS, Ibrahim F, Jafri SM, Shaikh H, Khan AH: Barrett's esophagus and Helicobacter pylori. J Gastroenterol Hepatol 10:331–333, 1995

    Google Scholar 

  25. Sirigu F, Capeccioni S, Dessi A, Masia AM: Helicobacter pylori in Barrett's esophagus and in normal or inflamed esophageal mucosa: a retrospective study. Rev Eur Sci Med Farmacol 16:131–134, 1994

    Google Scholar 

  26. Kogan Z, Corti R, Cabane A, Fiorini A, Monastra Varrica L, Fernandez Marty P, Vasen W: Helicobacter pylori enesafago de Barrett. Acta Gastroenterol Latinoam 22:215–219, 1992

    Google Scholar 

  27. Loffeld RJ, Ten Tije BJ, Arends JW: Prevalence and significance of Helicobacter pylori in patients with Barrett's esophagus. Am J Gastroenterol 87:1598–1600, 1992

    Google Scholar 

  28. Ferreres JC, Fernandez F, Rodrigue z Vives A, Gonzalez-Rodilla I, Ursua I, Ramos R, Val-Bernal JF: Helicobacter pylori in Barrett's esophagus. Histol Histopathol 6:403–408, 1991

    Google Scholar 

  29. Henihan RDJ, Stuart RC, Nolan N, Gorey TF, Hennessey TPJ, O'Morain CA: Barrett's esophagus and the presence of Helicobacter pylori. Am J Gastroenterol 93:542–546, 1998

    Google Scholar 

  30. IARC: Infection with Helicobacter pylori. In International Agency for Research of Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon, IARC, 1994, pp 177–240

  31. Asaka M, Takeda H, Sugiyama T, Kato M: What role does Helicobacter pylori play in gastric cancer? Gastroenterology 113( suppl 1):S56–S60, 1997

    Google Scholar 

  32. Genta RM, Ghrer IE, Graham DY, Krishnan B, Segura AM, Gutierrez O, Kim JG, Burchette JL Jr: Adherence of Helicobacter pylori to are as of incomplete intestinal me taplasia in the gastric mucosa. Gastroenterology 111:1206–1211, 1996

    Google Scholar 

  33. Morales TG, Sampliner RE, Bhattacharya A: Intestinal metaplasia of the gastric cardia. Am J Gastroenterol 92:414–418, 1997

    Google Scholar 

  34. Wright TA, Myskow M, Kingsnorth AN: Helicobacter pylori colonization of Barrett's esophagus and its progression to cancer. Dis Esophagus 10:196–200, 1997

    Google Scholar 

  35. Quaddus MR, Henley JD, Sulaiman RA, Palumbo TC, Gnepp DR: Helicobacter pylori and adenocarcinoma arising in Barrett's esophagus. Hum Pathol 28:1007–1009, 1997

    Google Scholar 

  36. Grimley CE, Loft DE, Morris AG, Nwokolo CU: Virulent Helicobacter pylori (HP) in patients with gastric and oesophageal adenocarcinoma. Gut 40( suppl 1):A2, 1997 (abstract)

    Google Scholar 

  37. Perez-Perez GI, Bhat N, Gaensbauer J, Fraser A, Taylor DN, Kuipers EJ, Zhang L, You WC, Balser MJ: Country-specific constancy by age in cagA + proportion of Helicobacter pylori infection. Int J Cancer 72:453–456, 1997

    Google Scholar 

  38. Chow W-H, Blaser MJ, Blot WJ, Gammon MD, Vaughan TL, Risch HA, Perez-Perez GI, Schoenberg JB, Rotterdam H, West AB, Fraumeni JF Jr: An inverse re lation between cagA + strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res 58:588–590, 1998

    Google Scholar 

  39. Richter JE, Falk GW, Vaezi MF: Helicobacter pylori and gastroesophage al reflux disease: The bug may not be all bad. Am J Gastroenterol 93:1800–1802, 1998

    Google Scholar 

Download references

Authors
  1. Virender K. Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Saba E. Demian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Donald Taillon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rajeev Vasudeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Colin W. Howden
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sharma, V.K., Demian, S.E., Taillon, D. et al. Examination of Tissue Distribution of Helicobacter pylori Within Columnar-Lined Esophagus. Dig Dis Sci 44, 1165–1168 (1999). https://doi.org/10.1023/A:1026628307895

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026628307895

Search

Navigation