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Dose-Dependent Effect of α-Tocopherol on Activity of Xenobiotic Metabolizing Enzymes in Rat Liver

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Abstract

Oral treatment with α-tocopherol for 4 days dose-dependently increased the content of cytochrome P450 (CYP), catalytic activities of CYP1A1, CYP1A2, CYP2B1, CYP2C, and activity of NADPH-cytochrome-P450 reductase in the liver of male rats, but did not change activity of glutathione S-transferase. These results suggest that α-tocopherol induced the enzymes of phase I of xenobiotic metabolism, including CYP1 and CYP2 families involved in the metabolism of drugs and procarcinogenes.

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Authors and Affiliations

  1. Laboratory of Foreign Compounds Biochemistry, Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk

    Yu. A. Sidorova, E. V. Ivanova, A. Yu. Grishanova & V. V. Lyakhovich

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  1. Yu. A. Sidorova
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  2. E. V. Ivanova
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  3. A. Yu. Grishanova
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  4. V. V. Lyakhovich
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Correspondence to Yu. A. Sidorova.

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Sidorova, Y.A., Ivanova, E.V., Grishanova, A.Y. et al. Dose-Dependent Effect of α-Tocopherol on Activity of Xenobiotic Metabolizing Enzymes in Rat Liver. Bulletin of Experimental Biology and Medicine 136, 38–41 (2003). https://doi.org/10.1023/A:1026080611490

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