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Reaction of Neurons to Alkaloid Agonists of Opioid Receptors during Modulation of Phosphodiesterases

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Abstract

We studied the effect of ultralow doses of theophylline and morphine, modulators of receptors and intracellular signal systems, on ion permeability of membranes. Theophylline and morphine in ultralow doses blocked the neuronal responses to these agents applied in physiological concentrations. Theophylline in ultralow doses attenuated, but did not completely block neuronal reaction to morphine. These findings suggest that ultralow doses of various substances producing no appreciable physiological changes can activate mechanisms providing optimum response to strong factors.

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Authors and Affiliations

  1. “Materia Medica Holding” Research-and-Production Company, Moscow

    O. I. Epstein, M. B. Shtark, T. A. Zapara, O. G. Simonova & A. S. Ratushnyak

  2. Siberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and Biophysics, Novosibirsk

    O. I. Epstein, M. B. Shtark, T. A. Zapara, O. G. Simonova & A. S. Ratushnyak

  3. Siberian Division of the Russian Academy of Sciences, Construction-and-Technological Institute of Computational Technologies, Novosibirsk

    O. I. Epstein, M. B. Shtark, T. A. Zapara, O. G. Simonova & A. S. Ratushnyak

Authors
  1. O. I. Epstein
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  2. M. B. Shtark
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  3. T. A. Zapara
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  4. O. G. Simonova
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  5. A. S. Ratushnyak
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Epstein, O.I., Shtark, M.B., Zapara, T.A. et al. Reaction of Neurons to Alkaloid Agonists of Opioid Receptors during Modulation of Phosphodiesterases. Bulletin of Experimental Biology and Medicine 135 (Suppl 7), 17–19 (2003). https://doi.org/10.1023/A:1024745705881

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  • DOI: https://doi.org/10.1023/A:1024745705881

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