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188Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy

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Abstract

The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ~99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.

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Authors and Affiliations

  1. Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan

    S. Pervez & A. Mushtaq

  2. Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan

    M. Arif

  3. Department of Chemistry, Islamia University, Bahawalpur, Pakistan

    Z. H. Chohan

Authors
  1. S. Pervez
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  2. A. Mushtaq
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  3. M. Arif
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  4. Z. H. Chohan
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Pervez, S., Mushtaq, A., Arif, M. et al. 188Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy. Journal of Radioanalytical and Nuclear Chemistry 256, 293–296 (2003). https://doi.org/10.1023/A:1023945603430

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  • DOI: https://doi.org/10.1023/A:1023945603430

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