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Mitochondrial Biogenesis in the Liver during Development and Oncogenesis

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Abstract

The analysis of the expression of oxidative phosphorylation genes in the liver during development reveals the existence of two biological programs involved in the biogenesis of mitochondria. Differentiation is a short-term program of biogenesis that is controlled at post-transcriptional levels of gene expression and is responsible for the rapid changes in the bioenergetic phenotype of mitochondria. In contrast, proliferation is a long-term program controlled both at the transcriptional and post-transcriptional levels of gene expression and is responsible for the increase in mitochondrial mass in the hepatocyte. Recently, a specific subcellular structure involved in the localization and control of the translation of the mRNA encoding the β-catalytic subunit of the H+-ATP synthase (β-mRNA) has been identified. It is suggested that this structure plays a prominent role in the control of mitochondrial biogenesis at post-transcriptional levels. The fetal liver has many phenotypic manifestations in common with highly glycolytic tumor cells. In addition, both have a low mitochondrial content despite a paradoxical increase in the cellular representation of oxidative phosphorylation transcripts. Based on the paradigm provided by the fetal liver we hypothesize that the aberrant mitochondrial phenotype of fast-growing hepatomas represents a reversion to a fetal program of expression of oxidative phosphorylation genes by the activation, or increased expression, of an inhibitor of β-mRNA translation.

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  1. Departamento de Biología Molecular, Centro de Biología Molecular “Severo Ochoa,” Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049, Madrid, Spain

    José M. Cuezva, Luciana K. Ostronoff, Javier Ricart, Miguel López de Heredia, Carlo M. Di Liegro & José M. Izquierdo

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  1. José M. Cuezva
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Cuezva, J.M., Ostronoff, L.K., Ricart, J. et al. Mitochondrial Biogenesis in the Liver during Development and Oncogenesis. J Bioenerg Biomembr 29, 365–377 (1997). https://doi.org/10.1023/A:1022450831360

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