Abstract
RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.
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Malgrange, B., Rogister, B., Lefebvre, P.P. et al. Expression of Growth Factors and Their Receptors in the Postnatal Rat Cochlea. Neurochem Res 23, 1133–1138 (1998). https://doi.org/10.1023/A:1020724506337
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DOI: https://doi.org/10.1023/A:1020724506337