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Bioactivity and mechanical properties of polydimethylsiloxane (PDMS)–CaO–SiO2 hybrids with different calcium contents

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Abstract

Polydimethylsiloxane (PDMS)–CaO–SiO2 hybrids with starting compositions containing PDMS/(Si(OC2H5)4+PDMS) weight ratio=0.30, H2O/Si(OC2H5)4 molar ratio=2, and Ca(NO3)2/Si(OC2H5)4 molar ratios=0–0.2, were prepared by the sol–gel method. The apatite-forming ability of the hybrids increased with increasing calcium content in the Ca(NO3)2/Si(OC2H5)4 molar ratio range 0–0.1. The hybrids with a Ca(NO3)2/Si(OC2H5)4 molar ratio range 0.1–0.2 formed apatite on their surfaces in a simulated body fluid (SBF) within 12 h. The hybrid with a Ca(NO3)2/Si(OC2H5)4 molar ratio of 0.10 showed an excellent apatite-forming ability in SBF with a low release of silicon into SBF. It also showed mechanical properties analogous to those of human cancellous bones. This hybrid is expected to be useful as a new type of bioactive material.

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Authors and Affiliations

  1. Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan

    M. Kamitakahara, M. Kawashita, N. Miyata & T. Kokubo

  2. Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    T. Nakamura

Authors
  1. M. Kamitakahara
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  2. M. Kawashita
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  3. N. Miyata
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  4. T. Kokubo
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  5. T. Nakamura
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Correspondence to M. Kamitakahara.

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Kamitakahara, M., Kawashita, M., Miyata, N. et al. Bioactivity and mechanical properties of polydimethylsiloxane (PDMS)–CaO–SiO2 hybrids with different calcium contents. Journal of Materials Science: Materials in Medicine 13, 1015–1020 (2002). https://doi.org/10.1023/A:1020324101682

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