Skip to main content
Log in

Leucine Enkephalin Effects on Brain Microvessel Endothelial Cell Monolayer Permeability

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. W. A. Banks and A. J. Kastin. A Brain-to-Blood Carrier-Mediated Transport System for Small, N-Tyrosinated Peptides. Pharmacol. Biochem. Behav. 21: 943–946 (1984).

    Google Scholar 

  2. W. A. Banks and A. J. Kastin. Effect of Neurotransmitters on the System that Transports Tyr-MIF-1 and the Enkephalins across the Blood-Brain Barrier: A Dominant Role for Serotonin. Psychopharmacology 98: 380–385 (1989).

    Google Scholar 

  3. W. A. Banks, A. J. Kastin, A. J. Fischman, D. H. Coy, and S. L. Strauss. Carrier-Mediated Transport of Enkephalins and N-Tyr-MIF-1 across Blood-Brain Barrier. Am. J. Physiol. 251: E477–E482 (1986).

    Google Scholar 

  4. W. A. Banks, A. J. Kastin, and E. A. Michals. Tyr-MIF-1 and Met-Enkephalin Share a Saturable Blood-Brain Barrier Transport System. Peptides 8: 899–903 (1987).

    Google Scholar 

  5. B. V. Zlokovic, M. N. Lipovac, D. J. Begley, H. Davson, and L. Rakic. Transport of Leucine-Enkephalin Across the Blood-Brain Barrier in the Perfused Guinea Pig Brain. J. Neurochem. 49: 310–315: (1987).

    Google Scholar 

  6. M. Baba, R. Oishi, K. Saeki. Enhancement of Blood-Brain Barrier Permeability to Sodium Fluorescein by Stimulation of μ-Opioid Receptors in Mice. Naunyn-Schmiedeberg's Arch. Pharmacol. 337: 423–428 (1988).

    Google Scholar 

  7. Itoh, R. Oishi, M. Nishibori, and K. Saeki. Involvement of mu Receptors in the Opioid-Induced Increase in Turnover of Mouse Brain Histamine. J. Pharmacol. Exp. Ther. 244: 1021–1026 (1988).

    Google Scholar 

  8. R. Oishi, M. Baba, M. Nishibori, Y. Itoh, and K. Saeki. Involvement of Central Histaminergic and Cholinergic Systems in the Morphine-Induced Increase in Blood-Brain Barrier Permeability to Sodium Fluorescein in Mice. Naunyn-Schmiedeberg's Arch. Pharmacol. 339: 159–165 (1989).

    Google Scholar 

  9. P. D. Bowman, S. R. Ennis, K. E. Rarey, A. L. Betz, and G. W. Goldstein. Brain Microvessel Endothelial Cells in Tissue Culture: A Model for Study of Blood-Brain Barrier Permeability. Ann. Neurol. 14: 396–402 (1983).

    Google Scholar 

  10. K. L. Audus and R. T. Borchardt. Characterization of an In Vitro Blood-Brain Barrier Model System for Studying Drug Transport and Metabolism. Pharm. Res. 3: 81–87 (1986).

    Google Scholar 

  11. K. L. Audus and R. T. Borchardt. Bovine Brain Microvessel Endothelial Cell Monolayers as a Model System for Blood-Brain Barrier. Ann N.Y. Acad. Sci. 507: 9–18 (1987).

    Google Scholar 

  12. D. W. Miller, K. L. Audus, and R. T. Borchardt. Application of Cultured Endothelial Cells of the Brain Microvasculature in the Study of the Blood-Brain Barrier. J. Tissue Culture Meth. 14: 217–224 (1992).

    Google Scholar 

  13. F. Shi and K.L. Audus. Biochemical Characteristics of Primary and Passaged Cultures of Primate Brain Microvessel Endothelial Cell Monolayers. Neurochem. Res. 19: 426–433 (1994).

    Google Scholar 

  14. F. L. Guillot, K. L. Audus, and T. J. Raub. Fluid-Phase Endocytosis by Primary Cultures of Bovine Brain Microvessel Endothelial Cell Monolayers. Microvas. Res. 39: 1–14 (1990).

    Google Scholar 

  15. T. J. Raub and K. L. Audus. Adsorptive Endocytosis and Membrane Recycling by Cultured Primary Brain Microvessel Endothelial Cell Monolayers. J. Cell Sci. 97: 127–138 (1990).

    Google Scholar 

  16. F. L. Guillot and K. L. Audus. Angiotension Peptide Regulation of Bovine Brain Microvessel Endothelial Cell Monolayer Permeability. J. Cardiovasc. Pharmacol. 18: 212–218 (1991).

    Google Scholar 

  17. F. Shi, J.L. Cavitt, C. Bailey, A.W. Malick, and K.L. Audus. Characterization of Dextromethorphan and Dextrorphan Uptake by a Putative Glutamic Acid Carrier and Passive Diffusion Across Brain Microvessel Endothelium. Drug Delivery 1: in press (1994).

  18. A. Baranczyk-Kuzma, K. L. Audus, and R. T. Borchardt. Catecholamine-Metabolizing enzymes of Bovine Brain Microvessel Endothelial Cell Monolayers. J. Neurochem. 46: 1956–1960 (1986).

    Google Scholar 

  19. S.E. Thompson and K.L. Audus. Leucine-Enkephalin Metabolism in Brain Microvessel Endothelial Cells. Peptides 15: 109–116 (1993).

    Google Scholar 

  20. I. L. Karnushina, J. M. Palacios, G. Barbin, E. Dux, F. Joo, and J.C. Schwartz. Studies on a Capillary-Rich Fraction Isolated from Brain: Histaminic Components and Characterization of the Histamine Receptors Linked to Adenylate Cyclase. J. Neurochem. 34: 1201–1208 (1980).

    Google Scholar 

  21. E. Dux and F. Joo. Effects of Histamine on Brain Capillaries. Exp. Brain Res. 47: 252–258 (1982).

    Google Scholar 

  22. P. M. Gross, G. M. Teasdale, W. J. Angerson, A. M. Harper, H2-Receptors Mediate Increases in Permeability of the Blood-Brain Barrier During Arterial Histamine Infusion. Brain Res. 210: 396–400 (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, S.E., Audus, K.L. Leucine Enkephalin Effects on Brain Microvessel Endothelial Cell Monolayer Permeability. Pharm Res 11, 1366–1369 (1994). https://doi.org/10.1023/A:1018971217897

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018971217897

Navigation