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Relationship Between Interdigestive Motility and Secretion of Immunoglobulin A in Human Proximal Small Intestine

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Abstract

In 17 healthy volunteers, we studied thedynamics of secretory immunoglobulin A (SIgA) release inthe proximal small intestine (distal duodenum andproximal jejunum), using a modified triple-lumenperfusion technique. Secretory data were related to thecurrent phase of the migrating motor complex (MMC), asrecorded by manometry. In both segments, luminal SIgAoutput changed cyclically, with peak outputs occurring at the end of the MMC cycle (late phase II).These MMC-related changes were due to two factors:cyclic inflow of SIgA from more proximal sites, and acyclic release of SIgA from the test segment thatcorrelated in time with an increase in epithelial fluidsecretion. Cyclic intestinal SIgA release may thus beanother secretory component of the MMC. The data arecompatible with the hypothesis that motility and SIgA release are linked by motility-activatedchloride secretion from the intestinal crypts.

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Authors
  1. Annika Mellander
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  2. Anna Mattsson
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  3. Ann-Mari Svennerholm
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  4. Henrik Sjovall
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Mellander, A., Mattsson, A., Svennerholm, AM. et al. Relationship Between Interdigestive Motility and Secretion of Immunoglobulin A in Human Proximal Small Intestine. Dig Dis Sci 42, 554–567 (1997). https://doi.org/10.1023/A:1018899110213

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  • DOI: https://doi.org/10.1023/A:1018899110213

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