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Plasma Cholecystokinin and Gallbladder Responses to Increasing Doses of Bombesin in Celiac Disease

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Abstract

Impaired postprandial gallbladder emptying inceliac disease has been attributed to an absence ofappropriate cholecystokinin release. To determine if aflat jejunal mucosa in celiac patients is related to a reduced cholecystokinin-secretingcapacity, increasing doses of bombesin were infused intosix patients with celiac disease and a flat jejunalmucosa (group A), in seven celiac patients with a normal jejunal mucosa while on a gluten-free diet(group B), and in seven healthy controls (group C).Bombesin induced significant (P < 0.05) increments ofplasma CCK to a maximum value of 1.0 ± 0.3 pM in group A, to 1.5 ± 0.3 pM in group B, andto 1.2 ± 0.3 pM in group C (NS between groups),that were accompanied by significant (P < 0.05)gallbladder emptying responses of 70 ± 4% ingroup A, 47 ± 10% in group B and 65 5% in group C.Dose-response relationships were not different betweengroups. We conclude that there is no major impairment ofgallbladder responsiveness to bombesin or ofcholecystokinin-secreting capacity in patients with a flat jejunal mucosadue to celiac disease.

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REFERENCES

  1. Mearin ML, Mulder CJJ: Celiac disease (gluten-sensitive enteropathy). InBockus Gastroenterology. WS Haubrich, F Schaffner, JE Berk (eds). Philadelphia, WB Saunders, 1995, pp 1027-1048

    Google Scholar 

  2. Marsh MN: Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ( “celiac sprue” ). Gastroenterology 102:330-354, 1992

    PubMed  Google Scholar 

  3. DiMagno EP, Go VLW, Summerskill WHJ: Impaired cholecystokinin - pancreozymin secretion, intraduodenal dilution, and maldigestion of fat in sprue. Gastroenterology 63:25-32, 1972

    PubMed  Google Scholar 

  4. Carroccio A, Iacono G, Montalto G, Cavataio F, Lorello D, Soresi M, Di Martino D, Notarbartolo A: Pancreatic insufficiency in celiac disease is not dependent on nutritional status. Dig Dis Sci 39:2235-2242, 1994

    PubMed  Google Scholar 

  5. Regan PT, DiMagno EP: Exocrine pancreatic insufficiency in celiac sprue: A cause of treatment failure. Gastroenterology 78:484-487, 1980

    PubMed  Google Scholar 

  6. Jansen JBMJ, Hopman WPM, Rosenbusch G, Lamers CBHW: Plasma cholecystokinin and gallbladder responses to intraduodenal fat and intravenous cholecystokinin in patients with coeliac disease. Eur J Gastroenterol Hepatol 4:349-353, 1992

    Google Scholar 

  7. Masclee AAM, Jansen JBMJ, Driessen WMM, Geuskens LM, Lamers CBHW: Correlation of gallbladder contraction with plasma cholecystokinin-like immunore activity during infusion of cerule in. Scand J Gastroenterol 26:1279-1284, 1991

    PubMed  Google Scholar 

  8. Brown AM, Bradshaw MJ, Richardson R, Wheeler JG, Harvey RF: Pathogenesis of the impaired gall bladder contraction of coeliac disease. Gut 28:1426-1432, 1987

    Google Scholar 

  9. Maton PN, Selden AC, Fitzpatrick ML, Chadwick VS: Defective gallbladder emptying and cholecystokinin release in celiac disease. Reversal by gluten-free diet. Gastroenterology 88:391-396, 1985

    PubMed  Google Scholar 

  10. Low-Beer TS, Harvey RF, Davies ER, Read AE: Abnormalities of serum cholecystokinin and gallbladder emptying in celiac disease. N Engl J Med 292:961-963, 1975

    PubMed  Google Scholar 

  11. Calam J, Ellis A, Dockray GJ: Identification and measurement of molecular variants of cholecystokinin in duodenal mucosa and plasma. Diminished concentrations in patients with coeliac disease. J Clin Invest 69:218-225, 1982

    PubMed  Google Scholar 

  12. Sjolund K, Alumets J, Berg NO, Hakanson R, Sundler F: Duodenal endocrine cells in adult coeliac disease. Gut 20:547-552, 1979

    PubMed  Google Scholar 

  13. Polak JM, Bloom SR, McCrossman MV, Timson CM, Johnston DR, Hudson D, Szelze M, Pearse AGE: Cholecystokinin abnormalities in coeliac disease. Gastroenterology 74:1079, 1978 (abstract)

    Google Scholar 

  14. Thimister PWL, Hopman WPM, Sloots CEJ, Rosenbusch G, Tangerman A, Willems HL, Lamers CBHW, Jansen JBMJ: Effect of bile salt binding or protease inactivation on plasma cholecystokinin and gallbladder responses to bombesin. Gastroenterology 107:1627-1635, 1994

    PubMed  Google Scholar 

  15. Jansen JBMJ, Lamers CBHW: Molecular forms of cholecystokinin in human plasma during infusion of bombesin. Life Sci 33:2197-2205, 1983

    Article  PubMed  Google Scholar 

  16. Jansen JBMJ, Lamers CBHW: Radioimmunoassay of cholecystokinin: Production and evaluation of antibodies. J Clin Chem Clin Biochem 21:387-394, 1983

    Google Scholar 

  17. Jansen JBMJ, Lamers CBHW: Radioimmunoassay of cholecystokinin in human tissue and plasma. Clin Chim Acta 131:305-316, 1983

    PubMed  Google Scholar 

  18. Everson GT, Braverman DZ, Johnson ML, Kern F: A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction. Gastroenterology 79:40-46, 1980

    Google Scholar 

  19. Hopman WPM, Brouwer WFM, Rosenbusch G, Jansen JBMJ, Lamers CBHW: A computerized method for rapid quantification of gallbladder volume from real-time sonograms. Radiology 154:236-237, 1985

    PubMed  Google Scholar 

  20. Elashoff JD: Down with multiple t-tests! Gastroenterology 80:615-620, 1981

    PubMed  Google Scholar 

  21. Hopman WPM, Rosenbusch G, Hectors MPC, Jansen JBMJ: Effect of predigested fat on intestinal stimulation of plasma cholecystokinin and gallbladder motility in coeliac disease. Gut 36:17-21, 1995

    PubMed  Google Scholar 

  22. Thimister PWL, Hopman WPM, Sloots CEJ, Rosenbusch G, Willems HL, Trijbels FJM, Jansen JBMJ: Role of intraduodenal proteases in plasma cholecystokinin and pancreaticobiliary responses to protein and amino acids. Gastroenterology 110:567-575, 1996

    PubMed  Google Scholar 

  23. Welton ML, Mantyh CR, Gates TS, Popper P, Vigna SR, Maggio JE, Passaro E, Mantyh PW: Localization of bombesin receptors in human gastrointestinal tract using quantitative receptor autoradiography. Regul Pept 19:144-145, 1987 (abstract)

    Google Scholar 

  24. Schjoldager B, Poulsen SS, Schmidt P, Coy DH, Holst JJ: Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am J Physiol 260:G577-G585, 1991

    PubMed  Google Scholar 

  25. Rouissi N, Rhaleb NE, Nantel F, Dion S, Drapeau G, Regoli D: Characterization of bombesin receptors in peripheral contractile organs. Br J Pharmacol 103:1141-1147, 1991

    PubMed  Google Scholar 

  26. Severi C, Grider JR, Makhlouf GM: Identification of separate bombesin and substance Preceptors on isolated muscle cells from canine gallbladder. J Pharmacol Exp Ther 245:195-198, 1988

    PubMed  Google Scholar 

  27. Parkman HP, Vozzelli MA, Pagano AP, Cowan A: Pharmacological analysis of receptors for bombesin-related peptides on guinea pig gallbladder smooth muscle. Regul Pept 52:173-180, 1994

    Article  PubMed  Google Scholar 

  28. Mitsukawa T, Takemura J, Nishizono F, Nakatsuru K, Ohgo S, Matsukura S: Effects of atropine, proglumide, and somatostatin analogue (SMS 201-995) on bombesin-induced gallbladder contraction. Am J Gastroenterol 84:1371-1374, 1989

    PubMed  Google Scholar 

  29. Douglas BR, Jebbink MCW, Tjon A, Tham RTO, Jansen JBMJ, Lamers CBHW: The effect of loxiglumide (CR-1505) on basal and bombesin-stimulated gallbladder volume in man. Eur J Pharmacol 166:307-309, 1989

    Article  PubMed  Google Scholar 

  30. Jebbink MCW, Jansen JBMJ, Mooy DM, Rovati LC, Lamers CBHW: Effect of the specific cholecystokinin-receptor antagonist loxiglumide on bombesin stimulated pancreatic enzyme secretion in man. Regul Pept 32:361-368, 1991

    Article  PubMed  Google Scholar 

  31. Braganza J, Howatt HT: Gallbladder inertia in celiac disease. Lancet 1:1133, 1971

    Article  Google Scholar 

  32. Colombato LO, Parodi H, Cantor D: Biliary function studies in patients with celiac sprue. Am J Dig Dis 22:96-98, 1977

    PubMed  Google Scholar 

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Authors
  1. Paul W. L. Thimister
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  2. Wim P. M. Hopman
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  3. Gerd Rosenbusch
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  4. Jan B. M. J. Jansen
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Thimister, P.W.L., Hopman, W.P.M., Rosenbusch, G. et al. Plasma Cholecystokinin and Gallbladder Responses to Increasing Doses of Bombesin in Celiac Disease. Dig Dis Sci 43, 668–672 (1998). https://doi.org/10.1023/A:1018844031460

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  • DOI: https://doi.org/10.1023/A:1018844031460

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