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Distinct Effects of Tetragastrin in Rat Gastroduodenal Mucosa on Mucin Content and Mucosal Protective Action Against Histamine-Induced Injury

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Abstract

We examined the effects of tetragastrin on mucin(mucus glycoprotein) content and mucosal damage in therat stomach and duodenum. Following an injection oftetragastrin (12, 120, or 400 μg/kg subcutaneously), no macroscopic damage was found to the gastricmucosa but an increase in corpus mucin content wasnoted, whereas mucosal lesions appeared and the mucincontent decreased in the duodenum in a dose-related manner. In the groups with histamine (0.8, 8,or 80 mg/kg intraperitoneally) administration, theextent of mucosal damage and the decrease in mucincontent were dose-related in both these regions. Forassessment of the effect of tetragastrin on the protectiveaction in gastroduodenal mucosa, changes in mucincontent and mucosal damage with histamine (80mg/kg)-induced injury were examined. Coadministration oftetragastrin prevented the gastric mucosal damage andinhibited the decrease in corpus mucin content. In theduodenum, tetragastrin aggravated the histamineinducedmucosal damage and did not inhibit the reduction of the mucin content. From the present results,the increase in gastric mucins induced by tetragastrinmight be related to the protective effect of gastricmucosa against injury. Tetragastrin did not protect the duodenal mucosa, and histamine-inducedinjury occurring in this region would be aggravated bythe increase in HCl secretion and the decrease in mucincontent induced by tetragastrin.

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Authors
  1. Yuichi Komuro
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  2. Kazuhiko Ishihara
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  3. Yoji Kojima
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  4. Katsunori Saigenji
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  5. Kyoko Hotta
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Komuro, Y., Ishihara, K., Kojima, Y. et al. Distinct Effects of Tetragastrin in Rat Gastroduodenal Mucosa on Mucin Content and Mucosal Protective Action Against Histamine-Induced Injury. Dig Dis Sci 43, 1050–1056 (1998). https://doi.org/10.1023/A:1018839003603

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