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Prostaglandins and Central Serotonergic Activity in the Rat

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Abstract

Pharmacological and biochemical studies indicate that prostaglandins (PGs) exert a modulatory influence on rat brain serotonergic activity. With several experimental approaches, it has been shown that PGEs and PGD2 facilitate central serotonergic activity in rats. On the contrary, PGF2α not only inhibits rat brain serotonergic activity but also antagonizes the facilitatory effect of the other PGs. The studies support the proposed neuromodulatory role for PGs in central synaptic transmission.

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References

  1. Coceani, F. (1974) Arch. Intern. Med. 133, 119–129.

    Google Scholar 

  2. Coceani, F., Pace-Asciak, C. R. (1976) in Prostaglandins: Physiological, Pharmacological and Pathological Aspects, Ed. Karim, M. M., pp. 1–36, MTP Press, Lancaster, Pennsylvania.

    Google Scholar 

  3. Wolfe, L. S. (1975) in Advances in Neurochemistry, Vol. 1, Eds. Agranoff, B. W., Aprison, M. H., pp. 1–49, Plenum Press, New York.

    Google Scholar 

  4. Wolfe, L. S. (1976) in Basic Neurochemistry, Eds. Siegel, C., Albers, R. W., Katzman, R., Agranoff, B. W., pp. 263–275, Little Brown, Boston.

    Google Scholar 

  5. Wolfe, L. S., Coceani, F. (1979) Annu. Rev. Physiol. 41, 669–684.

    Google Scholar 

  6. Mathé, A. A., Davis, K. L., Davis, B. M., Levy, M., Horvath, T. B (1981) in Biological Psychiatry 1981, Eds. Perris, C., Struwe, G., Jansson, B., pp. 679–682, Elsevier/North Holland, Amsterdam.

    Google Scholar 

  7. Hedqvist, P. (1977) Annu. Rev. Pharmacol. Toxicol. 17, 259–279.

    Google Scholar 

  8. Perez-Cruet, J., Haubrich, D. R., Weid, W. D. (1971) Pharmacologist 13, 278.

    Google Scholar 

  9. Haubrich, D. R., Perez-Cruet, J., Reid, W. D. (1973) Brit. J. Pharmacol. 48, 80–87.

    Google Scholar 

  10. Bhattacharya, S. K., Jaiswal, B. K., Reddy, P. K. S. P., Das, P. K. (1975) Indian J. Pharmacol. 7, 58–68.

    Google Scholar 

  11. Bhattacharya, S. K., Reddy, P. K. S. P., Debnath, P. K., Sanyal, A. K. (1975) Clin. Exp. Pharmacol. Physiol. 2, 353–357.

    Google Scholar 

  12. Srivastava, D. N., Bhattacharya, S. K., Sanyal, A. K. (1978) Clin. Exp. Pharmacol. Physiol. 5, 503–510.

    Google Scholar 

  13. Sanyal, A. K., Mishra, P. C., Gairola, R. L., Pandey, K. (1979) Indian J. Pharmacol. 11, 54.

    Google Scholar 

  14. Bose, R., Bhattacharya, S. K. (1979) Indian J. Med. Res. 70, 281–288.

    Google Scholar 

  15. Bhattacharya, S. K., Debnath, P. K., Mukhopadhyay, S. N., Sanyal, A. K. (1975) Indian J. Pharmacol. 7, 35–38.

    Google Scholar 

  16. Bhattacharya, S. K., Bose, R., Ghosh, P. (1978) Materia Med. Pol. 10, 194–197.

    Google Scholar 

  17. Bhattacharya, S. K., Mukhopadhyay, S. N., Debnath, P. K., Sanyal, A. K. (1976) Experientia 32, 907–908.

    Google Scholar 

  18. Bhattacharya, S. K., Sanyal, A. K. (1978) Prostaglandins Med. 1, 159–164.

    Google Scholar 

  19. Ghosh, P., Bhattacharya, S. K. (1980) Indian J. Med. Res. 72, 449–453.

    Google Scholar 

  20. Ghosh, P., Bose, R., Bhattacharya, S. K. (1980) Indian J. Med. Res. 72, 605–609.

    Google Scholar 

  21. Ghosh, P., Bhattacharya, S. K. (1978) Psychopharmacology 59, 293–297.

    Google Scholar 

  22. Bhattacharya, S. K., Ghosh, P., Sanyal, A. K. (1980) Indian J. Med. Res. 71, 955–960.

    Google Scholar 

  23. Bhattacharya, S. K., Ghosh, P., Bose, R. (1978) Materia Med. Pol. 9, 184–188.

    Google Scholar 

  24. Bhattacharya, S. K., Sanyal, A. K. (1978) Psychopharmacology 56, 235–237.

    Google Scholar 

  25. Ferreira, S. H. (1972) Nature 240, 200–203.

    Google Scholar 

  26. Collier, H. O. J., McDonald-Gibson, W. J., Saeed, S. A. (1974) Nature 252, 56–58.

    Google Scholar 

  27. Ferri, S., Santagostino, A., Braga, P. C., Galatulas, I. (1974) Psychopharmacology 39, 231–235

    Google Scholar 

  28. Sanyal, A. K., Bhattacharya, S. K., Keshary, P. R., Srivastava, D. N., Debnath, P. K. (1977) Clin. Exp. Pharmacol. Physiol. 4, 247–255.

    Google Scholar 

  29. Sanyal, A. K., Srivastava, D. N., Bhattacharya, S. K. (1979) Psychopharmacology 60, 159–163.

    Google Scholar 

  30. Bhattacharya, S. K., Mohan Rao, P. J., Bhattacharya, D. (1984) Pharm. Res. 5, 229–231.

    Google Scholar 

  31. Bhattacharya, S. K., Debnath, P. K., Sanyal, A. K. (1978) Indian J. Med. Res. 67, 848–853.

    Google Scholar 

  32. Bhattacharya, S. K. (1982) Neurosci. Lett. 33, 165–168.

    Google Scholar 

  33. Bhattacharya, S. K., Bhattacharya, D. (1982) J. Biosci. 4, 269–274.

    Google Scholar 

  34. Bhattacharya, S. K., Keshary, P. R., Sanyal, A. K. (1978) Eur. J. Pharmacol. 50, 83–85.

    Google Scholar 

  35. Bhattacharya, S. K., Bhattacharya, D. (1982) Indian J. Med. Res. 76, 632–636.

    Google Scholar 

  36. Bhattacharya, S. K., Bhattacharya, D. (1982) Indian J. Exp. Biol. 20, 406–408.

    Google Scholar 

  37. Bhattacharya, S. K. (1982) Asian J. Pharm. Sci. 4, 47–52.

    Google Scholar 

  38. Bhattacharya, S. K., Bhattacharya, D. (1982) Indian J. Pharmacol. 14, 217–222.

    Google Scholar 

  39. Bhattacharya, S. K., Ghosh, P. (1982) Indian J. Exp. Biol. 20, 788–790.

    Google Scholar 

  40. Bhattacharya, S. K., Parmar, S. S. (1985) Experientia (In Press).

  41. Bhattacharya, S. K., Ghosh, P. (1982) Indian J. Physiol. Pharmacol. 26, 162–167.

    Google Scholar 

  42. Hanukoglu, I. (1977) New Engl. J. Med. 296, 1414.

    Google Scholar 

  43. Bhattacharya, S. K., Bhattacharya, D. (1983) Z. Naturforsch. 38, 337–338.

    Google Scholar 

  44. Abdel-Halim, M. S., Hamberg, M., Sjoquist, B., Anggard, E. (1977) Prostaglandins 14, 633–643.

    Google Scholar 

  45. Laychock, S. G., Johnson, D. N., Harris, L. S. (1980) Pharmacol. Biochem. Behav. 12, 747–754.

    Google Scholar 

  46. Bhattacharya, S. K., Parmar, S. S. (1985) J. Pharm. Pharmacol. (In Press).

  47. Bhattacharya, S. K., Parmar, S. S. (1985) Pharm. Res. (In Press).

  48. Snyder, S. H., Axelrod, J., Zweig, M. (1965) Biochem. Pharmacol. 14, 831–835.

    Google Scholar 

  49. Neff, N. H., Lin, R. C., Ngai, S. H., Costa, E. (1969) in Advances in Biochemical Psychopharmacology, Vol. 1, Eds. Costa, E., Greengard, P., pp. 91–109, Raven Press, New York.

    Google Scholar 

  50. Sanyal, A. K., Srivastava, D. N., Bhattacharya, S. K. (1981) Indian J. Med. Res. 73, 787–792.

    Google Scholar 

  51. Debnath, P. K., Bhattacharya, S. K., Sanyal, A. K., Poddar, M. K., Ghosh, J. J. (1978) Biochem. Pharmacol. 27, 130–132.

    Google Scholar 

  52. Bhattacharya, S. K. (1982) Res. Comm. Chem. Pathol. Pharmacol. 38, 149–152.

    Google Scholar 

  53. Bhattacharya, S. K., Goodall, W. M., Brumleve, S. J., Parmar, S. S. (1985) Proc. Western Pharmacol. Soc. 28, 217–220.

    Google Scholar 

  54. Henker, D. P., Aiken, J. W. (1980) Eur. J. Pharmacol. 67, 155–158.

    Google Scholar 

  55. Bolla, J., Carson, G. D., Challis, J. R. G. (1977) Prostaglandins 14, 873–879.

    Google Scholar 

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Authors and Affiliations

  1. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India

    Salil K. Bhattacharya

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  1. Salil K. Bhattacharya
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Bhattacharya, S.K. Prostaglandins and Central Serotonergic Activity in the Rat. Pharm Res 2, 195–198 (1985). https://doi.org/10.1023/A:1016300424955

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