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Clearance of Radioactivity Deposited in the Respiratory Tract to Blood: Progress in a Multinational Interspecies Comparison Project

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Abstract

Due to the diversity of the chemical forms of radionuclides inhaled in industry and the environment, the assessment of intake and dose is based frequently on biokinetic studies of the materials in laboratory animals. The ICRP respiratory tract and systemic models provide an effective framework for extrapolating the results of such studies to humans, but there is a paucity of data concerning the crucial assumption that the absorption rates from lungs into blood for a given material are independent of the mammalian species. To address this uncertainty, biokinetic studies involving five chemical compounds and four mammalian species are being conducted. The compounds, with the species in parenthesis, are Pu-nitrate (man, primate, rat), Gd-oxide (man, primate, dog, rat), Np- oxide and nitrate (primate, rat), and U-octoxide (primate, dog, rat). This paper describes progress to date.

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References

  1. International Commission on Radiological Protection, Human respiratory tract model for Radiological protection, Elsevier Science Ltd., Oxford, ICRP Publication 66; Ann. ICRP24(1–3), 1994.

    Google Scholar 

  2. International Commission on Radiological Protection, Age-dependent doses to members of the public from intakes of radionuclides: Part 2, Ingestion dose coefficients, Elsevier Science Ltd., Oxford, ICRP Publication 67: Ann. ICRP 23(3/4), 1993.

    Google Scholar 

  3. International Commission on Radiological Protection, Age-dependent doses to members of the public from intakes of radionuclides; Part 3, Ingestion dose coefficients, Elsevier Science Ltd., Oxford, ICRP Publication 69: Ann. ICRP 25(1), 1995.

    Google Scholar 

  4. G. N. Stradling, P. G. Pellow, A. Hodgson, T. Fell, A. Phipps, M. Pearce, E. Rance, M. Ellender, M. Taskaeva, I. Penev, T. Guentchev, J. Radioanal. Nucl. Chem., 226 (1997) 7.

    Google Scholar 

  5. E. Ansoborlo, A. Hodgson, G. N. Stradling, S. A. Hodgson, H. Metivier, M-H Henge-Napoli, N. S. Jarvis, A. Birchall, Radiat. Prot. Dosim., 79 (1998) 23.

    Google Scholar 

  6. A. Espinosa, A. Aragon, G. N. Stradling, A. Hodgson, A. Birchall, Radiat. Prot. Dosim., 79 (1998) 161.

    Google Scholar 

  7. L. Bertelli, A. Puerta, M. E. Wrenn, J. L. Lipsztein, J. C. Moody, G. N. Stradling, A. Hodgson, T. P. Fell, Radiat. Prot. Dosim., 79 (1998) 87.

    Google Scholar 

  8. World Health Organization. Use of ionizing radiation and radionuclides on human beings for medical research, training and non-medical purposes, Technical Report Series 611, WHO, Vienna, 1977.

    Google Scholar 

  9. D. M. Taylor, T. M. Gillis, Radiat. Prot. Dosim., 53 (1994) No. 1–4, 1839.

    Google Scholar 

  10. S. N. Dmitriev, Y. T. Oganessian, G. Y. Starodub, S. V. Ssishkin, G. V. Buklanov, Y. P. Kharatinov, A. F. Novgorodov, Y. V. Yushevich, D. Newton, R. J. Talbot, Appl. Radiation Isotopes, 46 (1995) 307.

    Google Scholar 

  11. R. J. Talbot, D. Newton, S. N. Dmitriev, Radiat. Prot. Dosim., 71 (1997) 107.

    Google Scholar 

  12. D. Newton, R. J. Talbot, C. Kang, A. J. Warner, Radiat. Prot. Dosim., in press.

  13. M. Walsh, A. Black, N. Foord, J. Aerosol Sci., 8 (1977) 83.

    Google Scholar 

  14. A. Hodgson, J. C. Moody, G. N. Stradling, M. R. Bailey, J. W. Stather, Exp. Pathol., 37 (1989) 72.

    Google Scholar 

  15. M. R. Bailey, G. Etherington, G. N. Stradling, J. L. Poncy, P. Fritsch, G. Scheuch, W. G. Kreyling, J. Heyder, W. Hofmann, R. Bergman, A. Espinosa, A. Aragon, P. Camner, K. Philipson, M. Svartengren, B. E. Ansoborlo, M. H. Henge-Napoli, F. Paquet, G. Patrick, C. G. Collier, J. C. Strong, R. Falk, Inhalation of radionuclides, Mid-term report for research carried out under the auspices of the Nuclear Fission Safety Program of the European Commission. Report NRPB-M909, National Radiological Protection Board, Chilton, 1998.

    Google Scholar 

  16. M. Abel, R. B. Talbot, Pharmacol. Expt. Therapeutics, 157 (1967) 207.

    Google Scholar 

  17. R. J. Palmer, J. L. Butenhoff, J. B. Stevens, Environ. Res., 43 (1987) 142.

    Google Scholar 

  18. J. E. Craighead, J. Kleinerman, Arch. Pathol. Lab. Med., 12 (1988) 673.

    Google Scholar 

  19. P. J. Haley, Health. Phys., 61 (1991) 809.

    Google Scholar 

  20. A. J. Wasserman, T. M. Monticello, R. S. Feldman, P. H. Gitlitz, S. K. Durham, Toxicol. Pathol., 249 (1996) 588.

    Google Scholar 

  21. S. Hirano, K. T. Suzuki, Environ. Health Perspect., 104,Suppl. 1 (1996) 85.

    Google Scholar 

  22. A. J. Spencer, S. A. Wilson, J. Batchelor, A. Reid, J. Rees, E. Harpur, Toxicol. Pathol., 25 (1997) 245.

    Google Scholar 

  23. G. Oberdorster, in: Toxic and carcinogenic effects of solid particles in the respiratory tract, U. Mohr, D. L. Dungworth, J. L. Mauderly and G. Oberdorster (Eds), ILSI Press, Washington, D.C., 1994.

    Google Scholar 

  24. G. N. Stradling, G. Etherington, M. R. Bailey, Ethical approval document: Proposal for a study of the biokinetics of gadolinium-153 after inhalation as oxide and intravenous injection as citrate. Report NRPB M?, National Radiological Protection Board, Chilton, 1998.

    Google Scholar 

  25. International Commission on Radiological Protection, Dose coefficients for intakes of radionuclides by workers, Elsevier Science Ltd., Oxford, ICRP Publication 68; Ann. ICRP, 24(4), 1994.

    Google Scholar 

  26. International Commission on Radiological Protection, Age-dependent doses to members of the public from intake of radionuclides: Part 4 Inhalation dose coefficients, Elsevier Science Ltd., Oxford, ICRP Publication 71; Ann. ICRP, 25(3–4), 1995.

    Google Scholar 

  27. C. Lizon, P. Massiot, H. LeNour, G. Rateau, G. Grillon, M. Verry, S. Matton, P. Fritsch, Proc. 1996 Intern. Congress on Radiation Protection, IRPA 9, 14–19 April 1996, Vienna, p. 451.

  28. S. Andre, J. Charuau, G. Rateau, C. Vavasseur, H. Metivier, J. Aerosol Sci., 20 (1989) 647.

    Google Scholar 

  29. A. Birchall, M. R. Bailey, N. S. Jarvis, Proc. Intern. Conf. on Dose Management in the Nuclear Industry, Windermere, UK, 9–11 April 1995, p. 216.

  30. International Commission on Radiological Protection, Age-dependent doses to members of the public from intake of radionuclides, Part 5; Compilation of ingestion and inhalation dose coefficients. ICRP Publication 72; Ann. ICRP, 26(1). Oxford, Elsevier Science Ltd, 1996.

    Google Scholar 

  31. R. G. Cuddihy, B. B. Boecker, W. C. Griffith, Biochemical Implications of Radionuclides Released from Nuclear Industries, Vol. II, International Atomic Energy Agency, Vienna, 1979, p. 77.

    Google Scholar 

  32. M. B. Snipes, B. B. Boecker, R. O. McClennan, Toxicol. Appl. Pharmacol., 69 (1983) 345.

    Google Scholar 

  33. W. C. Griffith, R. G. Cuddihy, B. B. Boecker, R. A. Guilmette, M. A. Medinsky, J. A. Mewhinney, Health Phys., 45 (1983) 233.

    Google Scholar 

  34. M. R. Bailey, W. G. Kreyling plus seventeen authors, Ann. Occup. Hyg., 32,Suppl. 1 (1988) 975.

    Google Scholar 

  35. M. R. Bailey, W. G. Kreyling plus eighteen authors, J. Aerosol Sci., 20 (1989) 169.

    Google Scholar 

  36. W. G. Kreyling, S. Andre, C. G. Collier, G. A. Ferron, H. Metivier, G. Schumann, J. Aerosol. Sci., 22 (1991) 509.

    Google Scholar 

  37. W. G. Kreyling, A. Hodgson, R. A. Guilmette, C. Scarlett, A. Badmin, G. N. Stradling, Radiat. Prot. Dosim., 79 (1988) 241.

    Google Scholar 

  38. D. M. Taylor, R. W. Leggett, Radiat. Prot. Dosim. (in press).

  39. J. C. Moody, A. Hodgson, G. N. Stradling, M. R. Bailey, A. Birchall, Application of the ICRP human respiratory tract model to uranium compounds produced during the manufacture of nuclear fuel, NRPB Memorandum (in preparation).

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Authors and Affiliations

  1. National Radiological Protection Board, Chilton, Didcot, Oxon., UK

    N. Stradling, M. R. Bailey, A. Birchall, G. Etherington & A. Hodgson

  2. CEA/DSV/LRT, BP 12, 9160, Bruyères-le-Châtel, France

    P. Fritsch & J.-L. Poncy

  3. AEA Technology, Harwell, Didcot, Oxon., UK

    D. Newton

  4. GSF-Institute for Inhalation Biology, D-85758, Neuherberg, Germany

    W. Kreyling

  5. IPSN, Service de Dosimetry, BP 38, F-26701, Pierrelatte, France

    E. Ansoborlo

  6. Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA

    R. A. Guilmette

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  1. N. Stradling
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  4. G. Etherington
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  11. R. A. Guilmette
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Stradling, N., Bailey, M.R., Birchall, A. et al. Clearance of Radioactivity Deposited in the Respiratory Tract to Blood: Progress in a Multinational Interspecies Comparison Project. Journal of Radioanalytical and Nuclear Chemistry 243, 323–337 (2000). https://doi.org/10.1023/A:1016089006523

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