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The World of Pacing and Electropysiology: Report of the NASPE/NHLBI Round Table on Future Research Directions in Atrial Fibrillation

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References

  1. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983-988.

    Google Scholar 

  2. Furberg CD, Psaty BM, Manolio TA, Gardin JM, Smith VE, Rautaharju PM. Prevalence of atrial fibrillation in elderly subjects (The Cardiovascular Health Study). Am J Cardiol 1994;74:236-241.

    Google Scholar 

  3. Lake FR, Cullen KJ, de Klerk NH, McCall MG, Rosman DL. Atrial fibrillation and mortality in an elderly population. Aust NZ J Med 1989;19:321-326.

    Google Scholar 

  4. Phillips SJ, Whisnant JP, O'Fallon WM, Frye RL. Prevalence of cardiovascular disease and diabetes mellitus in residents of Rochester, Minnesota. Mayo Clin Proc 1990;65:344-359.

    Google Scholar 

  5. Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation; Analysis and implications. Arch Intern Med 1995;155:469-473.

    Google Scholar 

  6. Psaty BM, Manolio TA, Kuller LH, Kronmal RA, Cushman M, Fried LP, White R, Furberg CD, Rautaharju PM. Incidence of and risk factors for atrial fibrillation in older adults. Circulation 1997;96:2455-2461.

    Google Scholar 

  7. Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994;271:840-844.

    Google Scholar 

  8. Wolf PA, Benjamin EJ, Belanger AJ, Kannel WB, Levy D, D'Agostino RB. Secular trends in the prevalence of atrial fibrillation, The Framingham Study. Am Heart J 1996;131:790-795.

    Google Scholar 

  9. Stafford RS, Singer DE. National patterns of warfarin use in atrial fibrillation. Arch Intern Med 1996;156:2537-2541.

    Google Scholar 

  10. Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E, Bacharach P, Wilson PW, Benjamin EJ, D'Agostino RB. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 1994;331:1249-1252.

    Google Scholar 

  11. Ettinger PO, Wu CF, De La Cruz C, Jr., Weisse AB, Ahmed SS, Regan TJ. Arrhythmias and the “Holiday Heart”: alcohol-associated cardiac rhythm disorders. Am Heart J 1978;95:555-562.

    Google Scholar 

  12. Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, Brugada J, Girona J, Domingo A, Bachinski LL, Roberts R. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med 1997;336:905-911.

    Google Scholar 

  13. Allessie MA. Is atrial fibrillation sometimes a genetic disease? N Engl J Med 1997;336:950-951.

    Google Scholar 

  14. Vaziri SM, Larson MG, Benjamin EJ, Levy D. Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation 1994;89:724-730.

    Google Scholar 

  15. Ommen SR, Odell JA, Stanton MS. Atrial arrhythmias after cardiothoracic surgery. N Engl J Med 1997;336:1429-1434.

    Google Scholar 

  16. Polanczyk CA, Goldman L, Marcantonio ER, Orav EJ, Lee TH. Supraventricular arrhythmia in patients having noncardiac surgery: clinical correlates and effect on length of stay. Ann Intern Med 1998;129:279-285.

    Google Scholar 

  17. Aranki SF, Shaw DP, Adams DH, Rizzo RJ, Couper GS, VanderVliet M, Collins JJ, Cohn LH, Burstin HR. Predictors of atrial fibrillation after coronary artery surgery: current trends and impact on hospital resources. Circulation 1996;94:3890.

    Google Scholar 

  18. Kowey PR, Taylor JE, Rials SJ, Marinchak RA. Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting. Am J Cardiol 1992;69:963-965.

    Google Scholar 

  19. Daoud EG, Strickberger SA, Man KC, Goyal R, Deeb GM, Bolling SF, Pagani FD, Bitar C, Meissner MD, Morady F. Preoperative amiodarone as prophylaxis against atrial fibrillation after heart surgery. N Engl J Med 1997;337:1785-1791.

    Google Scholar 

  20. American Heart Association. 1998 Heart and Stroke Statistical Update, 1997.

  21. Lin HJ, Wolf PA, Kelly-Hayes M, Beiser AS, Kase CS, Benjamin EJ, D'Agostino RB. Stroke severity in atrial fibrillation: The Framingham Study. Stroke 1996;27:1760-1764.

    Google Scholar 

  22. Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: Analysis of pooled data from five randomized controlled trials. Arch Intern Med 1994;154:1449-1457.

    Google Scholar 

  23. Gajewski J, Singer RB. Mortality in an insured population with atrial fibrillation. JAMA 1981;245:1540-1544.

    Google Scholar 

  24. Krahn AD, Manfreda J, Tate RB, Mathewson FA, Cuddy TE. The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba Follow-Up Study. Am J Med 1995;98:476-484.

    Google Scholar 

  25. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: The Framingham Heart Study. Circulation 1998;98:946-952.

    Google Scholar 

  26. Vulpian A. Note sur les effets de la faradisation directe des ventricules du coeur chez le chien. Arch Physiol Norm Pathol 1874;1:975-980.

    Google Scholar 

  27. Moe GK, Abildskov JA. Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. Am Heart J 1959;58:59-70.

    Google Scholar 

  28. Lewis T. The Mechanism and Graphic Registration of the Heart Beat (3rd Ed). London: Shaw & Sons, 1925:319-374.

    Google Scholar 

  29. Moe GK, Rheinboldt WC, Abildskov JA. A computer model of atrial fibrillation. Am Heart J 1964;67:200-220.

    Google Scholar 

  30. Allessie MA, Lammers WEJEP, Bonke FIM, Hollen J. Experimental evaluation of Moe's multiple wavelet hypothesis of atrial fibrillation. In: Zipes DP and Jalife J, eds. Cardiac Electrophysiology and Arrhythmias. Orlando: Grune & Stratton, 1985;265-275.

    Google Scholar 

  31. Botteron GW, Smith JM. Quantitative assessment of the spatial organization of atrial fibrillation in the intact human heart. Circulation 1996;93:513-518.

    Google Scholar 

  32. Skanes AC, Mandapati R, Berenfeld O, Davidenko JM, Jalife J. Spatiotemporal periodicity during atrial fibrillation in the isolated sheep heart. Circulation 1998;1236-1248.

  33. Jalife J, Berenfeld O, Skanes AC, Mandapati R. Mechanisms of atrial fibrillation: Mother rotors or multiple daughter wavelets, or both? J Cardiovasc Electrophysiol 1998;9:S2-S12.

    Google Scholar 

  34. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339(10):659-666.

    Google Scholar 

  35. Saksena S, Giorgberidze I, Mehra R, Hill M, Prakash A, Krol RB, Mathew P. Electrophysiology and endocardial mapping of induced atrial fibrillation in patients with spontaneous atrial fibrillation. Am J Cardiol 1999;83:187-193.

    Google Scholar 

  36. Saksena S, Prakash A, Krol RB, Shankar A. Regional endocardial mapping of spontaneous and induced atrial fibrillation in patients with heart disease and refractory atrial fibrillation. Am J Cardiol 1999;84:880-889.

    Google Scholar 

  37. Cabo C, Pertsov AM, Baxter WT, Davidenko JM, Gray RA, Jalife J. Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle. Circ Res 1994;75:1014-1028.

    Google Scholar 

  38. Rohr S, Kucera JP, Fast VG, Kleber AG. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 1997;275:841-844.

    Google Scholar 

  39. Gray RA, Pertsov AM, Jalife J. Spatial and temporal organization during cardiac fibrillation. Nature 1998;392:75-78.

    Google Scholar 

  40. Schuessler RB, Kawamoto T, Hand DE, Mitsuno M, Bromberg BI, Cox JL, Boineau JP. Simultaneous epicardial and endocardial activation sequence mapping in the isolated canine right atrium. Circulation 1993;88:250-263.

    Google Scholar 

  41. Yue L, Feng J, Gaspo R, Li GR, Wang Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997;81:512-525.

    Google Scholar 

  42. Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. Two types of transient outward currents in adult human atrial cells. Am J Physiol 1987;252:H142-H148.

    Google Scholar 

  43. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res 1997;80:772-781.

    Google Scholar 

  44. Nattel S. Ionic determinants of atrial fibrillation and calcium channel abnormalities: cause, consequence, or innocent bystander. Circ Res 1999;85:473-476.

    Google Scholar 

  45. Hara M, Shvilkin A, Rosen MR, Danilo P Jr., Boyden PA. Steady state and nonsteady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms. Cardiovasc Res 1999:42:455-469.

    Google Scholar 

  46. Yue L, Feng J, Zhiguo W, Nattel S. Adrenergic modulation of the ultra-rapid delayed rectifier K+ current (Ikund) in canine atrial myocytes. (Abstract) Circulation 1998;98:I-610.

    Google Scholar 

  47. Gros D, Jarry-Guichard T, Ten Velde I, et al. Restricted distribution of connexin40, a gap junction protein, in mammalian heart. Circ Res 1994;74:839-851.

    Google Scholar 

  48. Saffitz JE, Kanter HL, Green KG, et al. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res 1994;74:1065-1070.

    Google Scholar 

  49. Fast VG, Kleber AG. Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc Res 1995;29:694-707.

    Google Scholar 

  50. Morillo CA, Klein GJ, Jones DL, Guiraudon CM. Chronic rapid atrial pacing: Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation 1995;91:1588-1595.

    Google Scholar 

  51. Pinto JM, Boyden PA. Electrical remodeling in ischemia and infarction. Cardiovasc Res 1999;42:284-297.

    Google Scholar 

  52. Rosenbaum MB, Blanco HH, Elizari MV, Lazzari JO, Davidenko JM. Electrotonic modulation of the T wave and cardiac memory. Am J Cardiol 1982;50(2):213-222.

    Google Scholar 

  53. Geller JC, Rosen MR. Persistent T-wave changes after alteration of the ventricular activation sequence. New insights into cellular mechanisms of cardiac memory. Circulation 1993;88:1811-1819.

    Google Scholar 

  54. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995;92:1954-1968.

    Google Scholar 

  55. Gaspo R, Bosch RF, Bou-Abboud E, Nattel S. Tachycardia-induced changes in Na+ current in a chronic dog model of atrial fibrillation. Circ Res 1997:81(6):1045-1052.

    Google Scholar 

  56. Feng J, Xu D, Wang Z, Nattel S. Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences. Am J Physiol 1998;275(2):H1717-1725.

    Google Scholar 

  57. Gaspo R, Sun H, Fareh S, Yeu L, Allen BG, Hebert TE, Nattel N. Biochemical mechanisms of reductions in calcium current caused by atrial tachycardia-induced electrical remodeling. (Abstract) Circulation 1998;98:1752A.

    Google Scholar 

  58. Tieleman RG, De Langen C, Van Gelder IC, de Kam PJ, Grandjean J, Bel KJ, Wijffels MC, Allessie MA, Crijns HJ. Verapamil reduces tachycardia-induced electrical remodeling of the atria. Circulation 1997;95:1945-1953.

    Google Scholar 

  59. Fareh H, Thibault B, Nattel S. Treatment with T-type calcium channel blocker prevents atrial fibrillation caused by tachycardia induced atrial remodeling. Circulation 1998;98:1088A.

    Google Scholar 

  60. Rockman HA. Koch WJ. Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J of Physiol 1997;272(2):H1553-1559.

    Google Scholar 

  61. Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E, Tomaselli GF. Ionic mechanisms of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 1996;78:262-273.

    Google Scholar 

  62. Li D, Feng J, Nattel S. Remodeling of atrial cellular and ionic electrophysiology by congestive heart failure. Circulation 1998;98:1749A.

    Google Scholar 

  63. Cohn JN, Levin TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic heart failure. N Engl J Med 1984;311:819-823.

    Google Scholar 

  64. Zhang L, Wang Z, Nattel S. Chronic adrenergic stimulation induces ionic remodeling in cultured adult guinea pig ventricular myocytes. Circulation 1998;98:1755A.

    Google Scholar 

  65. Ausma J, Wijffels M, Thone F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 1997;96:3157-3163.

    Google Scholar 

  66. Gaspo M, Bosch MR, Talajic M, Nattel S. Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. Circulation 1997;96(11):4027-4035.

    Google Scholar 

  67. Giorgberidze I, Saksena S, Krol RB, Prakash A, Munsif A, Mathew P. Catheter endocardial mapping of spontaneous termination of atrial fibrillation. (Abstract) PACE 1997;20:1065.

    Google Scholar 

  68. Courtemache M, Ramirez R, Nattel S. Ionic targets for drug therapy and AF-induced electrical remodeling: Insights from a human atrial action potential model. (Abstract) PACE 1998;21:437A.

    Google Scholar 

  69. Feng J, Wang Z, Li GR, Nattel S. Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes. J Pharmacol Experimental Therapeutics 1997;281:384-392.

    Google Scholar 

  70. Esmon C. The protein C anticoagulant pathway. Arterioscl Thromb 1992;12:135-145.

    Google Scholar 

  71. Esmon C. Cell mediated events that control blood coagulation and vascular injury. Annu Rev Cell Biol 1993;9:1-26.

    Google Scholar 

  72. Nemerson Y. Tissue factor and hemostasis. Blood 1988;71:1-8.

    Google Scholar 

  73. Edgington TS, Mackman N, Brand K, Ruf W. The structural biology of expression and function of tissue factor. Thromb Haemost 1991;66:67-79.

    Google Scholar 

  74. Carson SD, Brozna JP. The role of tissue factor in the production of thrombin. Blood Coagul Fibrinolysis 1993;4:281-292.

    Google Scholar 

  75. Pawashe A, Golino P, Ambrosio G, Migliaccio F, Ragni M, Pascucci I, Chiarello M, Garen A, Konigsberg W, Ezekowitz MD: A monoclonal antibody against rabbit tissue factor inhibits intravascular thrombosis. Circulation Res 1994;74(1):56-63.

    Google Scholar 

  76. Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: implications of disorders of hemostasis and thrombosis. Am J Pathol 1989;134:1087-1097.

    Google Scholar 

  77. Channon KM, Fulton GJ, Davies MG, Peters KG, Ezekowitz MD, Hagen PO, Annex BH. Modulation of tissue factor protein expression in experimental venous bypass grafts. Arterioscler Thromb Vasc Biol 1997;17:1313-1319.

    Google Scholar 

  78. Marmur JD, Rossikhina M, Guha A, Fyfe B, Friedrich V, Mendlowitz M, Nemerson Y, Taubman MB. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 1993;91:2253-2259.

    Google Scholar 

  79. Speidel CM, Eisenberg PR, Ruf W, Edgington TS, Abendschein DR. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. Circulation 1995;92:3323-3330.

    Google Scholar 

  80. Gilino P, Ragni M, Cirillo P, Avvidimento VE, Feliciello A, Esposito N, Scognamilio A, Trimaco B, Iaccarino G, Condorelli M, Chiariello M, Ambrosio G. Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion. Nat Med 1996;2:35-40.

    Google Scholar 

  81. Heiss WD, Forsting M, Dienes HC. Imaging in cardiovascular disease. Curr Opin Neurol 2001;14:67-75

    Google Scholar 

  82. Lake FR, Cullen KJ, de Klerk NH, McCall MG, Rosman DL. Atrial fibrillation and mortality in an elderly population. Aust NZ J Med 1989;19:321-326.

    Google Scholar 

  83. The National Institute of Neurological Disorders and Stroke rt-PA Study Group. Tissue plasminogen activation for acute ischemic stroke. N Engl J Med 1995;333:1581-1593.

    Google Scholar 

  84. Zito M, Muscari A, Marini E, et al. Silent lacunar infarcts in elderly patients with chronic nonvalvular atrial fibrillation. Aging 1996;8:341-346.

    Google Scholar 

  85. Ezekowitz MD, James KE, Nazarian SM, Davenport J, Broderick JP, Gupta SR, Thadani V, Meyer ML, Bridgers SL. For the Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators. Silent cerebral infarction in patients with nonrheumatic atrial fibrillation. Circulation 1995;92:2178-2182.

    Google Scholar 

  86. Baird AE, Warach S. Magnetic resonance imaging of acute stroke. J Cereb Blood Flow Metab 1998;18:583-609.

    Google Scholar 

  87. Tong DC, Albers GW. Transcranial Doppler-detected microemboli in patients with acute stroke. Stroke 1995;26:1588-1592.

    Google Scholar 

  88. Eldar M, Ohad DG, Goldberger JJ, Rotstein Z, Hsu S, Swanson DK, Greenspon AJ. Transcutaneous multielectrode basket catheter for endocardial mapping and ablation of ventricular tachycardia in the pig. Circulation 1997;96:2430-2437.

    Google Scholar 

  89. Pitschner HF, Berkovic A, Grumbrecht S, Neuzner J. Multielectrode basket catheter mapping for human atrial fibrillation. J Cardiovasc Electrophysiol 1998;9(Suppl):S48-S56.

    Google Scholar 

  90. Shpun S, Gepstein L, Hayamg G, Ben-Haim SA. Guidance of radiofrequency endocardial ablation with real-time three-dimensional magnetic navigation system. Circulation 1997;96:2016-2021.

    Google Scholar 

  91. Peters NS, Jackman WM, Schilling RJ, Beatty G, Davies DW. Human left ventricular endocardial activation mapping using a novel noncontact catheter. Circulation 1997;95:1658-1660.

    Google Scholar 

  92. Stellbrink C, Diem B, Schauert P, Ziegert K, Hanrath P. Transcoronary venous radiofrequency catheter ablation of ventricular tachycardia. J Cardiovasc Electrophysiol 1997;8:916-921.

    Google Scholar 

  93. Kuck K-H, Ernst S, Cappato R, et al. Nonfluoroscopic endocardial catheter mapping of atrial fibrillation. J Cardiovasc Electrophysiol 1998;9(Suppl):S57-S62.

    Google Scholar 

  94. Packer DP, Willis NP, Johnson SB. Guidance of linear lesion creation with a novel three dimensional intracardiac ultrasound ranging guidance system: A feasibility assessment. (Abstract) Circulation 1998;98:(Suppl I):1-643.

    Google Scholar 

  95. Wittkampf FH, Derksen R, Wever EF, Wilde AA. Loca Lisa: Electrical localization of endocardial electrodes. (Abstract) PACE 1997;20:1075.

    Google Scholar 

  96. Robb RA, Barillot C. Interactive display and analysis of 3-D medical images. IEEE Trans Med Imaging 1989;8(3):217-226.

    Google Scholar 

  97. Girouard SD, Pastore JM, Laurita KR, Gregory KW, Rosenbaum DS. Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit. Circulation 1996;93:603-613.

    Google Scholar 

  98. Cox JL, Canavan TE, Schuessler RB, et al. The surgical treatment of atrial fibrillation. II. Intraoperative electrophysiologic mapping and description of the electrophysiologic basis of atrial flutter and atrial fibrillation. J Thorac Cardiovasc Surg 1991;101:406-426.

    Google Scholar 

  99. Jais P, Haissaguerre M, Shah DC, Chouairi S, Gencel L, Hocini M, Clementy J. A focal source of atrial fibrillation treated by discrete radiofrequency ablation. Circulation 1997;95:572-576.

    Google Scholar 

  100. Swartz JF, Pellersels G, Silvers J, et al. A catheter-based curative approach to atrial fibrillation in humans. (Abstract) Circulation 1994;90(part 2):1-335.

    Google Scholar 

  101. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659-666.

    Google Scholar 

  102. Pappone C, Oreto G, Furlanello F, Loricchio ML, Vicedomini G, Bianchi S, Shpun S, D'Ascia C, Calabro MP, Dicandia C, Ben-Haim SA, Russo T, Chierchia S. Clinical impact of electroanatomically guided catheter compartmentation of human atria in the treatment of paroxysmal atrial fibrillation. G Ital Cardiol 1998;28:29-36.

    Google Scholar 

  103. Packer DL, Bednarek MC, Johnson SB. Chronic outcome of circumferential lesion creation in the pulmonary veins with a novel tandem balloon ablation catheter in dogs. (Abstract) Circulation 1998;98(Suppl I):I-642.

    Google Scholar 

  104. Liem LB, Mead RH, Shenasa M, Chun S, Hayase M, Kernoff R. Microwave catheter ablation using a clinical prototype system with a lateral fringe antenna design. PACE 1998;21:714-721.

    Google Scholar 

  105. Dubuc M, Talajic M, Roy D, Thibault B, Leung TK, Friedman PL. Feasibility of cardiac cryoablation using a transvenous steerable electrode catheter. J Intervent Card Electrophysiol 1998;2:285-292.

    Google Scholar 

  106. Solbiati L. New applications of ultrasonography: interventional ultrasound. Eur J Radiol 1998;27(Suppl 2):S200-S206.

    Google Scholar 

  107. Weber HP, Heinze A, Zhuang S. Laser catheter ablation of chronic persistent atrial fibrillation. (Abstract) PACE 1999;22:A26.

    Google Scholar 

  108. Haissaguerre M, Gencel L, Fischer B, Clementy J. Successful catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 1994;5:1045-1052.

    Google Scholar 

  109. Coumel P, Friocourt P, Mugica J, Attuel P, LeClercq JF. Long-term prevention of vagal atrial arrhythmias by atrial pacing at 90/minute: Experience with 6 cases. PACE 1983;6:552-560.

    Google Scholar 

  110. Attuel P, Pellerin D, Mugica J, et al. DDD pacing: An effective treatment modality for recurrent atrial arrhythmias. PACE 1988;11:1647-1654.

    Google Scholar 

  111. Andersen HR, Nielsen JC, Thomsen PEB, Thuesen L, Mortensen PT, Vesterlund T, Pedersen AK. Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome. Lancet 1997;305:1210-1216.

    Google Scholar 

  112. Connolly SJ, Kerr CR, Gent Meral; Proberts RS, Yusaf S, Gillis AM, Sami MH, Talajic M, Tang AS, Klein GJ, Lau C, Newman DM. Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. CToff investigators, New Engl J Med 2000;342:1385-1391

    Google Scholar 

  113. Gillis AM, Connolly SJ, Yee R, Dubuc M, Phillipon F, Lacombe P, Kerr CR, Wyse DG for the PA3 Investigators. Atrial pacing peri-ablation for paroxysmal atrial fibrillation—Phase I. (Abstract) PACE 1998;21(II):872.

    Google Scholar 

  114. Saksena S, Prakash A, Hill M, Krol RB, Munsif AN, Mathew PP, Mehra R. Prevention of recurrent atrial fibrillation with chronic dual site right atrial pacing. J Am Coll Cardiol 1996;28:687-694.

    Google Scholar 

  115. Delfaut P, Saksena S, Prakash A, Krol RB. Long-term outcome of patients with drug-refractory atrial flutter and fibrillation after single and dual site right atrial pacing for arrhythmia prevention. J Am Coll Cardiol 1998;32:1900-1908.

    Google Scholar 

  116. Daubert C, Mabo PH, Berder V, Gras D, Leclercq C. Atrial tachyarrhythmias associated with high degree interatrial conduction block: prevention by permanent atrial resynchronisation. Eur J Cardiac Pacing Electrophysiol 1994;1:35-44.

    Google Scholar 

  117. Prakash A, Delfaut P, Krol RB, Saksena S. Regional right and left atrial activation patterns during single and dual site atrial pacing in patients with atrial fibrillation. Am J Cardiol 1998;82:1197-1204.

    Google Scholar 

  118. Murgatroyd FD, Nitzsche R, Slade AKB, et al. A new pacing algorithm for overdrive suppression of atrial fibrillation. PACE 1994;17:1966-1973.

    Google Scholar 

  119. Ricci R, Puglisi A, Azzolini P, Spampinato A, Bellocci F, Padeletti L, Capucci A, Boriani G, Marchini A, Cavaglia S, De Seta F. Consistent atrial pacing algorithm to suppress recurrent paroxysmal atrial fibrillation: A randomized prospective cross over study. (Abstract) PACE 1998;21(II):798.

    Google Scholar 

  120. Cooper RAS, Plumb VJ, Epstein AE, Kay GN, Ideker RE. Marked Reduction in internal atrial defibrillation thresholds with dual-current pathways and sequential shocks in humans. Circulation 1998;97:2527-2535.

    Google Scholar 

  121. Saksena S, Prakash A, Mongeon L, Varanasi S, Kolettis T, Mathew P, DeGroot P, Mehra R, Krol RB. Clinical efficacy and safety of atrial defibrillation using biphasic shocks and current nonthoracotomy endocardial lead configurations. Am J Cardiol 1995;76:913-921.

    Google Scholar 

  122. Tse HF, Lau CP. Is there a role for cardioversion of very chronic atrial fibrillation by transvenous atrial defibrillation. (Abstract) J Am Coll Cardiol 1998;31(2):332A.

    Google Scholar 

  123. Wellens HJJ, Lau C-P, Lüderitz B, Akhtar M, Waldo AL, Camm AJ, Timmermans C, Tse H-F, Jung W, Jordaens L, Ayers G. For the METRIX Investigators. Atrioverter: An implantable device for the treatment of atrial fibrillation. Circulation 1998;98:1651-1656.

    Google Scholar 

  124. Jung W, Lüderitz B. Implantation of an arrhythmia management system for ventricular and supraventricular tachyarrhythmias. Lancet 1997;349:853-854.

    Google Scholar 

  125. Lerman B, Stein K, Markowitz S. For the Worldwide 7250 Clinical Investigators. Worldwide clinical experience with the Model 7250 Jewel AF dual chamber arrhythmia management device. (Abstract) PACE 1998;21(II):872.

    Google Scholar 

  126. Bailin SJ, Sulke N, Swerdlow C. For the Jewel AF only investigators. Clinical experience with a dual chamber implantable cardioverter defibrillator in patients with atrial fibrillation and flutter. (Abstract) PACE 1999:22:871.

    Google Scholar 

  127. Jung J, Heisel A, Fries R, Kollner V. Tolerability of internal low-energy shock strengths currently needed for endocardial atrial cardioversion. Am J Cardiol 1997;80:1489-1490.

    Google Scholar 

  128. Kleine P, Liebold A, Blommaert D. Interim results of a multicenter trial of temporary epicardial surgical wires used for the treatment of postoperative atrial fibrillation. (Abstract) PACE 1998;21(II):807.

    Google Scholar 

  129. Giorgberidze I, Saksena S, Mongeon L, Mehra R, Krol RB, Munsif AN, Mathew P. Effects of high-frequency atrial pacing in atypical atrial flutter and atrial fibrillation. J Intervent Card Electrophysiol 1997;1:111-123.

    Google Scholar 

  130. Jung W, Wolpert C, Spehl S, Tenser D, Schumacher B, Esmailzadeh B, Lüderitz B. A prospective randomized comparison of high frequency burst pacing with antitachycardia ramp pacing for termination of induced atrial tachycardias. (Abstract) J Am Coll Cardiol 1998;31(2):357A.

    Google Scholar 

  131. Prakash A, Saksena S, Mathew P, Krol R. Internal atrial defibrillation: Effect on sinus and atrioventricular nodal function and implanted cardiac pacemakers. PACE 1997;20:2434-2441.

    Google Scholar 

  132. Danias PG, Caulfield TA, Weigner MJ, Silverman DI, Manning WJ. Likelihood of atrial fibrillation to sinus rhythm. J Am Coll Cardiol 1998;31:588-592.

    Google Scholar 

  133. Dell'Orfano JT, Patel H, Wolbrette DL, Luck JC, Naccarelli GV. Acute treatment of atrial fibrillation: spontaneous conversion rates and cost of care. Am J Cardiol 1999;83:785-790.

    Google Scholar 

  134. Capucci A, Boriani G, Rubino I, Della Casa S, Sanguinetti M, Magnani B. A controlled study on oral propafenone versus digoxin plus quinidine in converting recent onset atrial fibrillation to sinus rhythm. Int J Cardiol 1994;43:305-313.

    Google Scholar 

  135. Boriani G, Biffi M, Capucci A, Luca Botto G, Broffoni T, Rubino I, Della Casa S, Sanguinetti M, Magnani B. Oral propafenone to convert recent-onset atrial fibrillation in patients with and without underlying heart disease. Ann Intern Med 1997;126:621-625.

    Google Scholar 

  136. Galve E, Rius T, Ballester R, Artaza M, Arnau JM, Garcia-Dorado D, Soler-Soler J. Intravenous amiodarone in treatment of recent-onset atrial fibrillation: results of a randomized, controlled study. J Am Coll Cardiol 1996;27:1079-1082.

    Google Scholar 

  137. Stambler BS, Wood MA, Ellenbogen KA, Perry KT, Wakefield LK, VanderLugt JT, and the Ibutilide Repeat Dose Study Investigators. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Circulation 1996;94:1613-1621.

    Google Scholar 

  138. Volgman AS, Carberry PA, Stambler B, Lewis WR, Dunn GH, Perry KT, VanderLugt JT, Kowey PR. Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation. J Am Coll Cardiol 1998;31:1414-1419.

    Google Scholar 

  139. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. N Engl J Med 1999;341:857-865.

    Google Scholar 

  140. Kowey PR, VanderLugt JT, Luderer JR. Safety and risk/benefit analysis of ibutilide for acute conversion of atrial fibrillation/flutter. Am J Cardiol 1996;78(Suppl 8A):46-52.

    Google Scholar 

  141. Crijns HJ, van Gelder IC, Lie KI. Supraventricular tachycardia mimicking ventricular tachycardia during flecainide treatment. Am J Cardiol 1988;62:1303-1306.

    Google Scholar 

  142. Feld GK, Chen P-S, Nicod P, Fleck RP, Meyer D. Possible atrial proarrhythmic effects of class IC antiarrhythmic drugs. Am J Cardiol 1990;66:378-383.

    Google Scholar 

  143. Brignole M, Menozzi C, Gianfranchi L, et al. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacologic treatment in patients with heart failure and chronic atrial fibrillation. Circulation 1998;98:953-960.

    Google Scholar 

  144. Natale A, Zimerman L, Tomassoni G, et al. Impact on ventricular function and quality of life of transcatheter ablation of the atrioventricular junction in chronic atrial fibrillation with a normal ventricular response. Am J Cardiol 1996;78:1431-1433.

    Google Scholar 

  145. Fitzpatrick AD, Kourouyan HD, Siu A, et al. Quality of life and outcomes after radiofrequency His bundle catheter ablation and permanent pacemaker implantation: impact of treatment in paroxysmal and established atrial fibrillation. Am Heart J 1996;131:499-507.

    Google Scholar 

  146. Geelen P, Goethals M, de Bruyere B, Brugada P. A prospective hemodynamic evaluation of patients with chronic atrial fibrillation undergoing radiofrequency catheter ablation of the atrioventricular junction. Am J Cardiol 1997;80:1606-1609.

    Google Scholar 

  147. Heinz G, Siostrozonek P, Kreiner G, Gossinger H. Improvement in left ventricular systolic function after successful radiofrequency His bundle ablation for drug refractory, chronic atrial fibrillation and recurrent atrial flutter. Am J Cardiol 1992;69:489-492.

    Google Scholar 

  148. Gianfranchi L, Brignole M, Menozzi C, Lolli G, Bottoni N. Progression of permanent atrial fibrillation after atrioventricular junction ablation and dual-chamber pacemaker implantation in patients with paroxysmal atrial tachyarrhythmias. Am J Cardiol 1998;81:351-354.

    Google Scholar 

  149. Kay GN, Ellenbogen KA, Giudici M, Redfield MM, Jenkins LS, Mianulli M, Wilkoff B and the APT Investigators. The Ablate and Pace Trial: A prospective study of catheter ablation of the AV conduction system and permanent pacemaker implantation for treatment of atrial fibrillation. J Intervent Cardiac Electrophysiol 1998;2:121-135.

    Google Scholar 

  150. Lee SH, Chen SA, Tai CT, Chiang CE, Wen ZC, Cheng JJ, Ding YA, Chang MS. Comparisons of quality of life and cardiac performance after complete atrioventricular junction ablation and atrioventricular junction modification in patients with medically refractory atrial fibrillation. J Am Coll Cardiol 1998;31(3):637-644.

    Google Scholar 

  151. Lown B, Amarasingham R, Neuman J. New method for terminating cardiac arrhythmias—use of synchronised capacitor discharge. JAMA 1962;182:548-555.

    Google Scholar 

  152. Lown B, Perlroth MG, Bey SK, Abe T. “Cardioversion” of atrial fibrillation. A report on the treatment of 65 episodes in 50 patients. N Engl J Med 1963;269:325-331.

    Google Scholar 

  153. Falk RH. Current management of atrial fibrillation. Curr Opin Cardiol 1994;9:30-39.

    Google Scholar 

  154. Ewy GA. The optimal technique for electrical cardioversion of atrial fibrillation. Clin Cardiol 1994;17:79-84.

    Google Scholar 

  155. Ricard P, Levy S, Trigano J, Paganelli F, Daoud E, Man KC, Strickberger SA, Morady F. Prospective assessment of the minimum energy needed for external electrical cardioversion of atrial fibrillation. Am J Cardiol 1997;79:815-816.

    Google Scholar 

  156. Golzari H, Cebul RD, Bahler RC. Atrial fibrillation: Restoration and maintenance of sinus rhythm and indications for anticoagulation therapy. Ann Intern Med 1996;125:311-323.

    Google Scholar 

  157. Dalzell GW, Anderson J, Adgey AA. Factors determining success and energy requirements for cardioversion of atrial fibrillation. Quart J Med 1990;76:903-913.

    Google Scholar 

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Saskena, S., Domanski, M.J., Benjamin, E.J. et al. The World of Pacing and Electropysiology: Report of the NASPE/NHLBI Round Table on Future Research Directions in Atrial Fibrillation. J Interv Card Electrophysiol 5, 345–364 (2001). https://doi.org/10.1023/A:1011489306778

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