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The complex structures of arabinogalactan-proteins and the journey towards understanding function

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Abstract

Arabinogalactan-proteins (AGPs) are a family of complex proteoglycans found in all higher plants. Although the precise function(s) of any single AGP is unknown, they are implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death. DNA sequencing projects have made possible the identification of the genes encoding a large number of putative AGP protein backbones. In contrast, our understanding of how AGPs undergo extensive post-translational modification is poor and it is important to understand these processes since they are likely to be critical for AGP function. Genes believed to be responsible for post-translational modification of an AGP protein backbone, include prolyl hydroxylases, glycosyl transferases, proteases and glycosylphosphatidylinositol-anchor synthesising enzymes. Here we examine models for proteoglycan function in animals and yeast to highlight possible strategies for determining the function(s) of individual AGPs in plants.

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Authors and Affiliations

  1. Plant Cell Biology Research Centre, University of Melbourne, 3010, Australia

    Yolanda Gaspar, Kim L. Johnson, James A. McKenna & Antony Bacic

  2. Cooperative Research Centre for Bioproducts, University of Melbourne, 3010, Australia

    Carolyn J. Schultz

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  1. Yolanda Gaspar
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Gaspar, Y., Johnson, K.L., McKenna, J.A. et al. The complex structures of arabinogalactan-proteins and the journey towards understanding function. Plant Mol Biol 47, 161–176 (2001). https://doi.org/10.1023/A:1010683432529

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