References
Paget J. On a form of chronic inflammation of bones (osteitis deformans). Med Chir Tr 1877;60:37-63.
Gold DT, Boisture J, Shipp KM, Pieper CF, Lyles KW. Paget's disease of bone and quality of life. J Bone Miner Res 1996;11:1897-1904.
Kaplan FS. Severe orthopaedic complications of Paget's disease. Bone 1999;24:43S-46S.
Siris ES. Paget's disease of bone. J Bone Miner Res 1998;13:1061-1065.
Siris ES, Clemens TP, McMohan D, Gordon AG, Jacobs TP, Canfield RE. Parathyroid function in Paget's disease of bone. J Bone Miner Res 1989;4:75-79.
Meunier PJ, Coindre JM, Edouard CM, Arlot ME. Bone histomorphometry in Paget's disease: quantitative and dynamic analysis of Pagetic and non-pagetic bone tissue. Arthritis Rheum 1980;23:1095-1103.
Whyte MP, Daniels EH, Murphy WA. Osteolytic Paget's bone disease in a young man. Am J Med 1985;78:326-332.
Cooper C, Schafheutle K, Dennison E, Kellingray S, Guyer P, Barker D. The epidemiology of Paget's disease in Britain: Is the prevalence decreasing? J Bone Miner Res 1999;14:192-197.
Morales-Piga AA, Rey-Rey JS, Corres-Gonzalez J, Garcia-Sagredo JM, Lopez-Abente G. Frequency and characteristics of familial aggregation of Paget's disease of bone. J Bone Miner Res 1995;10:663-670.
Siris ES, Ottman R, Flaster E, Kelsey JL. Familial aggregation of Paget's disease of bone. J Bone Miner Res 1991;6:495-500.
Cody JD, Singer FR, Roodman GD, Otterund B, Lewis TB, Leppert M. Genetic linkage of Paget's disease of the bone to chromosome 18q. Am J Hum Genet 1997;61:1117-1122.
Hughes AF, Shearmen AM, Weber JL, Barr RJ, Wallace RG, Osterberg PH, Nevin NC, Mollan RAB. Genetic linkage of familial expansile osteolysis to chromosome 18q. Hum Mol Genet 1994;3:359-361.
Haslam SI, Van Hul W, Morales-Piga A, Balemans W, SanMillan JL, Nakatsuka K, Willems P, Haites NE, Ralston SH. Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity. J Bone Miner Res 1998;13:911-917.
Nellissery MJ, Padalecki SS, Brkanac Z, Singer FR, Roodman GD, Unni KK, Leach RJ, Hansen MF. Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget's disease of bone. Am J Hum Genet 1998;63:817-824.
Singer FR, Roodman GD. Paget's Disease of Bone: Principles of Bone Biology. San Diego, CA: Academic Press Inc. 1996;969-977.
Rebel A, Malkani K, Basle J. Anomalies nucleaires des osteoclasts de la maladie osseuse de Paget. Nouv Presse Med 1974;3:1299-1301.
Mills BG, Singer FR. Nuclear inclusions in Paget's disease of bone. Science 1976;194:201-202.
Basle MF, Fournier JG, Rozenblatt S, Rebel A, Boutielle M.Measles virus mRNA detected in Paget's disease bone tissue by in situ hybridization. J Gen Virol 1986;67:907-913.
Gordon MT, Anderson DC, Sharpe PT. Canine distemper virus localized in bone cells of patients with Paget's disease. Bone 1991;12:195-201.
Gordon MT, Mee AP, Anderson DC, Sharpe PT. Canine distemper virus transcripts sequenced from Pagetic bone. Bone Miner 1992;19:159-174.
Singer FR. Update on the viral etiology of Paget's disease of bone. J Bone Miner Res 1999;14:29-33.
Reddy SV, Singer FR, Roodman GD. Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence. J Clin Endocrinol Metab 1995;80:2108-2111.
Reddy SV, Singer FR, Mallette L, Roodman GD. Detection of measles virus nucleocapsid transcripts in circulating blood cells from patients with Paget's disease. J Bone Miner Res 1996;11:1602-1607.
Gordon MT, Mee AP, Anderson DC, Sharpe PT. Canine distemper virus transcripts sequenced from Pagetic bone. J Bone Miner Res 1992;19:159-174.
Mee AP. Paramyxoviruses and Paget's disease: the affirmative view. Bone 1999;24:19S-21S.
Ralston SH, Digiovine FS, Gallacher SJ, Boyle IT, Duff GW. Failure to detect paramyxovirus sequences in Paget's disease of bone using the polymerase chain reaction. J Bone Miner Res 1991;6:1243-1248.
Birch MA, Taylor W, Fraser WD, Ralston SH, Hart CA, Gallagher JA. Absence of paramyxovirus RNA in cultures of Pagetic bone cells and in Pagetic bone. J Bone Miner Res 1994;9:11-16.
Kurihara N, Reddy SV, Menaa C, Roodman GD. Measles virus nucleocapsid gene transfer to human bone marrow cells induces a Pagetic phenotype in normal osteoclasts. J Bone Miner Res 1999;14:S182.
Rota JS, Heath JL, Rota PA, King GE, Celma ML, Carabana J, Fernandez-Munoz R, Brown D, Jin JL, Bellini WJ. Molecular epidemiology of measles virus: identification of pathways of transmission and implications for measles elimination. J Infect Dis 1996;173:32-37.
Reddy SV, Menaa C, Singer FR, Cundy T, Cornish J, Whyte MP, Roodman GD. Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone. J Exp Hematol 1999;27:1528-1532.
Gherardi G, Lo Cascio V, Bonucci E. Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone. Histopathology 1980;4:63-74.
Kukita A, Chenu C, McManus LM, Mundy GR, Roodman GD. Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease. J Clin Invest 1990;85:1280-1286.
Mills BG, Frausto A, Singer FR, Ohsaki Y, Demulder A, Roodman GD. Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens. Bone 1994;15:443-448.
Demulder A, Takahashi S, Singer FR, Hosking DJ, Roodman GD. Abnormalities in osteoclast precursors and the marrow accessory cells in Paget's disease. Endocrinology 1993;133:1978-1982.
Menaa C, Barsony J, Reddy SV, Cornish J, Cundy T, Roodman GD. 1,25-dihydroxyvitamin D3 sensitivity of osteoclast precursors from patients with Paget's disease. J Bone Miner Res 2000;15:1-9.
Menaa C, Reddy SV, Bruder J, Anderson D, Cornish J, Cundy T, Kurihara N, Roodman GD. Enhanced RANK ligand expression and responsivity in Paget's disease. J Bone Miner Res 1999;14:S143.
Lacey DL, Timms E, Tan HL, Kelley MJJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176.
Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR. Interleukin-6: A potential autocrine/paracrine factor in Paget's disease of bone. J Clin Invest 1992;89:46-52.
Hoyland JA, Freemont AJ, Sharpe PT. Interleukin-6, IL-6 receptor and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res 1994;9:75-80.
Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. Interleukin-6 stimulates osteoclast like multinucleated cell formation in long-term human marrow cultures by inducing IL-1 release. J Immunol 1990;144:426-430.
Hoyland J, Sharpe PT. Upregulation of c-fos protooncogene expression in Pagetic osteoclasts. J Bone Miner Res 1994;9:1191-1194.
Ralston SH, Hoey SA, Gallacher SJ, Adamson BB, Boyle IT. Cytokine and growth factor expression in Paget's disease: analysis by reverse-transcription/polymerase chain reaction. Br J Rheum 1994;33:620-625.
Hughes DE, Wright KE, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 1995;10:1478-1487.
Rogers MJ, Watts DJ, Russell RGG. Overview of bisphosphonates. Cancer 1997;15(Suppl. 1):1652-1660.
Thiebaud D, Jaeger P, Gobelet C, Jacquet AF, Burckhardt P. A single infusion of the bisphosphonate AHPrBP (APD) as treatment of Paget's disease of bone. Am J Med 1988;85:207-212.
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Reddy, S.V., Kurihara, N., Menaa, C. et al. Paget's Disease of Bone: A Disease of the Osteoclast. Rev Endocr Metab Disord 2, 195–201 (2001). https://doi.org/10.1023/A:1010010912302
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DOI: https://doi.org/10.1023/A:1010010912302