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Statistical Parameters in Behavioral Tasks and Implications for Sample Size of C57BL/6J:129S6/SvEvTac Mixed Strain Mice

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Abstract

Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.

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Authors and Affiliations

  1. Department of Biochemistry, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX, 75390-8573

    Sandi Jo Estill & Kathleen Fay

  2. Department of Internal Medicine, Molecular Cardiology Division, 5323 Harry Hines Blvd., Dallas, TX, 75390-8573

    Joseph A. Garcia

Authors
  1. Sandi Jo Estill
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  2. Kathleen Fay
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  3. Joseph A. Garcia
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Estill, S.J., Fay, K. & Garcia, J.A. Statistical Parameters in Behavioral Tasks and Implications for Sample Size of C57BL/6J:129S6/SvEvTac Mixed Strain Mice. Transgenic Res 10, 157–175 (2001). https://doi.org/10.1023/A:1008955016170

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