Abstract
Using data froma case-control study in the United States (the Selected Cancers Study), weexamined the relationship between non-Hodgkin's lymphoma (NHL) and family history of different cancers. Cases were 1,511 men aged 31 to 59 years and diagnosed pathologically with non-Hodgkin's lymphoma during 1984-88. Controls were men, frequency-matched to cases by age range and cancer registry (n = 1,910). All study subjects with acquired immunodeficiency syndrome were excluded from analyses. Our results showed that the risk of NHL is associated with a history of lymphoma (odds ratio [OR] = 3.0, 95 percent confidence interval [CI] = 1.7-5.2) and hematologic cancer (OR = 2.0, CI = 1.2-3.4) in first-degree relatives after adjustment for age, ethnic background, and educational level. Further analyses were performed for the subgroups defined by age at diagnosis (younger than 45 years cf 45 years or older). The association of NHL with a family history of lymphoma and hematologic cancer was found primarily among men aged 45 and older (OR = 4.1, CI = 1.9-8.8 for lymphoma and OR = 2.3, CI = 1.3-4.0 for hematologic cancer). The association among men aged 45 and older did not vary by whether or not there were any familial patients diagnosed at the age of 45 or older. No significant associations could be found for a family history of lung cancer, breast cancer, prostate cancer, colon cancer, skin cancer, liver cancer, stomach cancer, brain cancer, thyroid cancer, or myeloma. This study suggests that the familial risk of NHL is influenced primarily by hematolymphoproliferative malignancies rather than other cancers. The familial effects of hema-tolymphoproliferative malignancies may be stronger for men aged 45 to 59, compared with those aged 31 to 44.
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References
Haim N, Cohen Y, Robinson E. Malignant lymphoma in first-degree blood relatives. Cancer1982; 49: 2197–200.
Bjerrum OW, Hasselbalch HC, Drivsholm A, Nissen NI. Non-Hodgkin malignant lymphomas and Hodgkin's disease in first-degree relatives: evidence for a mutual genetic predisposition? Scan J Haematol1986; 36: 398–401.
Lynch HT, Marcus JN, Weisenburger DD, et al. Genetic and immunopathological findings in a lymphoma family. Br J Cancer1989; 59: 622–6.
Eriksson M, Bergstrom I. Familial malignant blood disease in the county of Jamtland, Sweden. Eur J Haematol1987; 38: 241–5.
Fraumeni JF Jr, Wertelecki W, Blattner WA, Jensen RD, Leventhal BG. Varied manifestations of a familial lymphoproliferative disorder. Am J Med1975; 59: 145–51.
Blattner WA, Dean JH, Fraumeni JF Jr. Familial lymphoproliferative malignancy: clinical and laboratory follow-up. Ann Intern Med1979; 90: 943–4.
Law IP, Herberman RB, Oldham RK, Bouzoukis J, Hanson SM, Rhode MC. Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies: Clinical description. Cancer1977; 39: 1224–8.
Clark JW, Tucker MA, Greene MH. Clinical and laboratory observations in a lymphoma-prone family. Cancer1987; 60: 864–9.
Cartwright RA, McKinney PA, O'Brien C, et al. Non-Hodgkin's lymphoma: case control epidemiological study in Yorkshire. Leuk Res1988; 12: 81–8.
Pottern LM, Linet M, Blair A, et al. Familial cancers associated with subtypes of leukemia and non-Hodgkin's lymphoma. Leukemia1991; 15: 305–14.
Bihan CL, Moutou C, Chompret A, et al. Cancers in relatives of children with non-Hodgkin's lymphoma. Leuk Res1996; 20: 181–6.
Khoury MJ, Beaty TH, Cohen BH. Fundamentals of Genetic Epidemiology. New York, NY (USA): Oxford University Press, 1993: 1–25.
The Selected Cancers Cooperative Study Group. The association of selected cancers with service in the US military in Vietnam. I. Non-Hodgkin's Lymphoma. Arch Intern Med1990; 150: 2473–83.
World Health Organization. International Classification of Disease for Oncology. First Edition. Geneva, Switzerland: WHO, 1976.
Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol. 1. The Analysis of Case-Control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.
Hosmer D Jr, Lemeshow S. Applied Logistic Regression. New York, NY (USA): John Wiley & Sons, 1990.
Weisenburger DD. Pathological classification of non-Hodgkin's lymphoma for epidemiological studies. Cancer Res1992; 52: 5456s–64s.
Sackett DL. Bias in analytic research. J Chron Dis1979; 32: 51–68.
Neugebauer R, Ng S. Differential recall as a source of bias in epidemiological research. J Clin Epidemiol1990; 43: 1337–41.
Jandl JH. Blood: Textbook of Hematology. Boston, MA (USA): Little, Brown and Company, 1987.
Hoffman R, Benz EJ, Jr., Shattil SJ, Furie B, Cohen HJ. Hematology: Basic Principles and Practice. New York, NY (USA): Churchill Livingstone, 1991.
Aisenberg AC. Coherent view of non-Hodgkin's lymphoma. J Clin Oncol1995; 13: 2656–75.
Mueller N. Overview: viral agents and cancer. Environ Health Perspect1995; 103 (Suppl 8): 259–61.
Potolsky AI, Heath CW, Buckley CE, III, Rowlands DT Jr. Lymphorecticular malignancies and immunologic abnormalities in a sibship. Am J Med1971; 50: 42–8.
Greene MH, Miller RW. Familial non-Hodgkin lymphoma: histologic diversity and relation to other cancers.Am J Med Genet1978; 1: 437–43.
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Zhu, K., Levine, R.S., Gu, Y. et al. Non-Hodgkin's lymphoma and family history of malignant tumors in a case-control study (United States). Cancer Causes Control 9, 77–82 (1998). https://doi.org/10.1023/A:1008853421083
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DOI: https://doi.org/10.1023/A:1008853421083