Abstract
Four institutes from three countries in the European Union have collaborated under the BRITE–EURAM framework programme for the development of processing technologies for resorbable osteosynthesis devices. The devices should be continuous-fibre reinforced, and the technology should offer the possibility of orienting the fibres in the main trajectories. Poly-L-lactide and poly-L–DL-lactides have been synthesized for reinforcement fibres and matrix material, respectively. Melt-spun P-L-LA fibres of a strength of 800 MPa have been embedded in an amorphous P-L–DL-LA 70 : 30 matrix by compression moulding. Ethyleneoxide sterilized samples have been tested in vitro and in vivo. A satisfying bending modulus has been reached (6 GPa). Yet with 50% strength retention after ten weeks, fast degradation occurred that could be related to residual monomers. By this fast degradation 70% resorption after one year could be observed in the non-functional animal studies in rabbits. There was only a mild inflammatory reaction, which confirmed the good biocompatibility of the materials even during the resorption period. Further effort has to concentrate on the reduction of initial monomer content. The great advantage of the processing method to orient fibres in the device will be utilized in prototype samples, e.g. an osteosynthesis plate with fixation holes. © 1998 Chapman & Hall
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References
A. J. Tonino, C. L. Davidson, P. J. Klopper and L. A. Linclau, J. Bone and Joint Surg. 58 (1976) 107.
L. Claes, Biomed. Technik 34 (1989) 315.
C. Gabrielsson, C. Larsson, L. E. Ericson and P. Thomson, In the Eleventh European Conference on Biomaterials, Pisa, Italy, 10-14 September, 1994 p. 325.
D. H. Hourane, UK Patent 2 1811 438 A (1987).
Phusis matériaux biorésorbables, information brochure; Les Phusilines, Malvaisin, Z. A. F-38420 Le Versoud, France.
Synthes, information brochure Polypin 2.0; article No. 016.175 1/94, Synthes GmbH, Im Kirchenhurstle 4-6, D-79224 Umkirch, Germany.
S. VainionpÄÄ, A. Majola, M. Mero, K. Vihtonen, A. MÄkelÄ, J. Vasenius, P. Rokkanen and P. TÖrmÄlÄ, Biomaterials 88 Trans. XI (1988) 500.
Y. Matsusue, T. Yamamuro, M. Oka, Y. Shikinami, S.-H. Hyon and Y. Ikada, J. Biomed. Mater. Res. 26 (1992) 1553.
M. Fini, S. Giannini, R. Giardino, G. Giavaresi, M. Grimaldi, N. Nicoli Aldini, L. Orienti and M. Rocca, Int. J. Artific. Organs 18 (1995) 772.
A. Morales and F. K. Ko, In Thirty-Fourth International SAMPE Symposium, Vol. 34, 2 edited by G. A. Zakrewski, Don-Mazenko, S. T. Peters and C. D. Dean (eds) (1989) pp. 1929-39.
R. J. Coldicott, T. Longdon, S. Green and P. J. Ives, ibid. pp. 2206-14.
S. J. Crandall, US Patent 4 275 117 (1981).
H. Planck, EP Patent DE 40 30 815 A1 (1990).
J. W. Leenslag and A. J. Pennings, Polymer 28 (1987) 1695.
Y. Ikada, K. Jamshidi, H. Tsuji and S.-H. Hyon, Macromol. 20 (1987) 904.
L. Claes, Praxis Forum 20190, Technik und Kommunikationsverlags GmbH, Berlin (1990) pp 84-93.
G. O. Hofmann and F. D. Wagner, Clin. Mater. 14 (1993) 207.
M. Dauner, H. Hierlemann, E. MÜller and H. Planck, In the Twelfth European Conference on Biomaterials, Porto, Portugal 10-13 September, 1995.
S. M. Li, H. Garreau and M. Vert, J. Mater. Sci. Mater. Med. 1 (1990) 123, 131, 198.
S. A. M. Ali, P. J. Doherty and D. F. Williams, J. Biomed. Mater. Res. 27 (1993) 1409.
R. Gutwald, H. Pistner, J. Reuther and J. MÜhling, J. Mater. Sci. Mater. Med. 5 (1994) 485.
L. Claes, K. Rehm and D. Hutmacher, In the Fourth World Biomaterials Congress, Transactions (1992) p. 205.
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Dauner, M., Planck, H., Caramaro, L. et al. Resorbable continuous-fibre reinforced polymers for osteosynthesis. Journal of Materials Science: Materials in Medicine 9, 173–179 (1998). https://doi.org/10.1023/A:1008823804460
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DOI: https://doi.org/10.1023/A:1008823804460