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The Interaction of Mitogen-Activated Protein Kinases to Epstein-Barr Virus Activation in Akata Cells

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Abstract

To understand the mechanism by which Epstein-Barr virus (EBV) is activated in Akata cells by cross-linking of surface immunoglobulin, the interaction between mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and EBV activation was investigated. Immunoblotting using an anti-phosphoMAPK antibody (Ab) revealed that anti-IgG Ab induced rapid phosphorylation of MAPK in the cells. The phosphorylation was inhibited by MAPK/ERK kinase specific inhibitor, PD98059. The expressions of the EBV immediate early BZLF1 mRNA and its protein product ZEBRA, and early antigen were also inhibited by the inhibitor. These results indicate that MAPK is involved in the pathways of EBV activation.

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Authors and Affiliations

  1. Department of Biosignaling, School of Life Science, Faculty of Medicine, Tottori University, Yonago, 683

    Tomohisa Satoh, Yoshiko Hoshikawa, Yukio Satoh & Takeshi Sairenji

  2. Department of Pathology, National Institute of Infectious Diseases, Tokyo, 162, Japan

    Takeshi Kurata

Authors
  1. Tomohisa Satoh
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  2. Yoshiko Hoshikawa
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  3. Yukio Satoh
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  4. Takeshi Kurata
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  5. Takeshi Sairenji
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Satoh, T., Hoshikawa, Y., Satoh, Y. et al. The Interaction of Mitogen-Activated Protein Kinases to Epstein-Barr Virus Activation in Akata Cells. Virus Genes 18, 57–64 (1999). https://doi.org/10.1023/A:1008021402908

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