Abstract
Complementary DNA clones representing the fusion (F) protein gene of the porcine rubulavirus LPMV were isolated and sequenced. The F gene was found to be 1,845 nucleotides long containing one long open reading frame capable of encoding a protein of 541 amino acids. The cleavage motif for F0 into F1 and F2 is His-Arg-Lys-Lys-Arg. A sequence comparison and a phylogenetic analysis was performed in order to identify possible functional domains of paramyxovirus fusion proteins and also to classify the porcine rubulavirus. The F gene of LPMV is most closely related to the human mumps virus and simian virus type 5 F genes, and is therefore classified into the rubulavirus genus. A coding region for a small hydrophobic protein was however not found between the F and hemagglutinin-neuraminidase (HN) genes as previously found in both SV5 and mumps.
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Sundqvist, A., Bergvall, AC., MORENO-LO´PEZ, J. et al. Analysis of the Fusion Protein Gene of the Porcine Rubulavirus LPMV: Comparative Analysis of Paramyxovirus F Proteins. Virus Genes 14, 55–61 (1997). https://doi.org/10.1023/A:1007987407250
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DOI: https://doi.org/10.1023/A:1007987407250