Abstract
We conducted this experiment to assess the effect of saline injection in electrochemical therapy. Platinum electrodes using direct current were inserted into egg white or liver parenchyma. Pure water or 0.9%, 3%, or 26% sodium chloride were injected into various objects to compare with the control group (no injection). Power was set at 10 V. In the egg-white experiment, gas bubbles and coagulated protein developed around the electrodes. In ex vivo liver, frothy reddish debris developed around the cathodes, while a hardening and shrunken surface occurred around the anodes. The pH was 14 around the cathodes, 0 around the anodes. The electric current, the amount of coagulated protein, and the severity of tissue damage were all in proportion to the concentrations of the injected saline. The volume destroyed in the 26% saline group was 8.1 times larger than that of the control group. Therefore, injected saline, especially saturated saline, can enhance the effect of electrochemical therapy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Nordenstrom BEW: The paradigm of biologically closed electric circuits (BCEC) and the formation of an international association (IABC) for BCEC systems. Eur J Surg 574(suppl):7-23, 1994
Xin YL: Organization and spread of electrochemical therapy in China. Eur J Surg 574(suppl):25-30, 1994
Xin YL: Advances in the treatment of malignant tumors by electrochemical therapy. Eur J Surg 574(suppl):31-36, 1994
Nordenstrom BEW: Clinical trials of electrophoretic ionization in the treatment of malignant tumors. IRCS Med Sci 6:537, 1987
Nordenstrom BEW: Survey of mechanisms in electrochemical treatment (ECT) of cancer. Eur J Surg 574(suppl):93-109, 1994
Matsushima Y, Takahashi E, Hagiwara K, Konaka C, Miura H, Kato H, Koshiishi Y: Clinical and experimental studies of antitumoural effects of electrochemical therapy (ECT) along or in combination with chemotherapy. Eur J Surg 574(suppl):59-67, 1994
Jaak B, Daniel S: Electrochemical aspects of treatment of tissue with direct current. Eur J Surg 574(suppl):111-115, 1994
Shake JG, Larson DW, Salerno CT, Bianco RW, Bolman RM 3rd. The role of electrolyte in lesion size using an irrigated radiofrequency electrode. J Invest Surg 10:339-346, 1997
Livraghi T, Goldberg SN, Monti F, Bizzini A, Lazzaroni S, Meloni F, Pellicano S, Solbiati L, Gazelle GS: Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 202:205-210, 1997
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lin, XZ., Jen, CM., Chou, CK. et al. Saturated Saline Enhances the Effect of Electrochemical Therapy. Dig Dis Sci 45, 509–514 (2000). https://doi.org/10.1023/A:1005489022649
Issue Date:
DOI: https://doi.org/10.1023/A:1005489022649