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The chemoselective alkynylation of dihaloquinolines by the Sonogashira—Hagihara reaction

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Abstract

Conditions for the regioselective Sonogashira—Hagihara alkynylation of 4-chloro-6-iodo(bromo)quinolines were found and 6-alkynyl-4-chloroquinolines were obtained in 90—100% yields.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 119992, Moscow, Russian Federation

    I. P. Beletskaya, G. V. Latyshev, A. V. Tsvetkov & N. V. Lukashev

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  1. I. P. Beletskaya
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  2. G. V. Latyshev
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  3. A. V. Tsvetkov
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  4. N. V. Lukashev
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Correspondence to I. P. Beletskaya.

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Beletskaya, I.P., Latyshev, G.V., Tsvetkov, A.V. et al. The chemoselective alkynylation of dihaloquinolines by the Sonogashira—Hagihara reaction. Russian Chemical Bulletin 53, 189–193 (2004). https://doi.org/10.1023/B:RUCB.0000024849.57521.49

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  • DOI: https://doi.org/10.1023/B:RUCB.0000024849.57521.49

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