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The Incremental Group Testing Model for Gap Closing in Sequencing Long Molecules

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Abstract

In this paper, we propose the incremental group testing model for the gap closing problem, which assumes that we can tell the difference between the outcome of testing a subset S, and the outcome of testing S ∪ {x}. We also give improvements over currently best results in literature for some other models.

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References

  1. R. Beigel, N. Alon, S. Kasif, M.S. Apaydin, and L. Fortnow, “An optimal procedure for gap closing in whole genome shotgun sequencing,” in Proceedings of the Fifth Annual International Conference on Computational Biology, Montreal, Quebec, Canada, 2001, pp. 22–30.

  2. L.J. Burgart, R.A. Robinson, M.J. Heller, W.W. Wilke, O.K. Iakoubova, and J.C. Cheville, “Multiplex polymerase chain reaction,” Mod. Pathol., vol. 5, pp. 320–323, 1992.

    Google Scholar 

  3. P. Damaschke, “A tight upper bound for group testing in graphs,” Discrete Applied Math., vol. 48, pp. 101–109, 1994.

    Google Scholar 

  4. D.-Z. Du and F.K. Hwang, Combinatorial Group Testing and its Applications, Series on Applied Mathematics, 2nd ed. World Scientific: Singapore, 2000.

    Google Scholar 

  5. V. Grebinski and G. Kucherov, “Reconstructing a Hamiltonian cycle by querying the graph: Application to DNA physical mapping,” Discrete Applied Math., vol. 88, pp. 147–165, 1998.

    Google Scholar 

  6. V. Grebinski and G. Kucherov, “Optimal reconstruction of graphs under the additive model,” Algorithmica, vol. 28, pp. 104–124, 2000.

    Google Scholar 

  7. M. Hell, Combinatorial Theory, 2nd ed. Wiler Interscience: New York, 1996.

    Google Scholar 

  8. P. Johann, “Agroup testing problem for graphs with several defective edges,” Discrete Applied Math., vol. 117, pp. 99–108, 2002.

    Google Scholar 

  9. B. Lindstrom, “On a combinatorial problem in number theory,” Canad. Math. Bull., vol. 8, pp. 261–265, 1965.

    Google Scholar 

  10. B. Lindstrom, “Determination of two vectors from the sum,” J. Combin. Thy., vol. A6, pp. 402–407, 1969.

    Google Scholar 

  11. J. Nagura, “On the interval containing at least one prime number,” Proc. Japan Acad., vol. 28, pp. 177–181, 1952.

    Google Scholar 

  12. A. Sorokin, A. Lapidus, V. Capuano, N. Galleron, P. Pujic, and S.D. Ehrlich, “A new approach using multiplex long accurate PCR and yeast artifical chromosomes for bacterial chromosome mapping and sequencing,” Genome Res., vol. 6, pp. 448–453, 1996.

    Google Scholar 

  13. G. Tenenbaum, The Prime Numbers and Their Distribution. AMS: USA, 2000.

    Google Scholar 

  14. H. Tettelin, D. Radune, S. Kasif, H. Khouri, and S.L. Salzberg, “Optimized multiplex PCR: Efficiently closing a whole-genome shotgun sequencing project,” Genomics., vol. 62, pp. 500–507, 1996.

    Google Scholar 

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Hwang, F.K., Lin, WD. The Incremental Group Testing Model for Gap Closing in Sequencing Long Molecules. Journal of Combinatorial Optimization 7, 327–337 (2003). https://doi.org/10.1023/B:JOCO.0000017381.11696.c6

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  • DOI: https://doi.org/10.1023/B:JOCO.0000017381.11696.c6

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