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Neurotransmitter Modulation of Neuronal Calcium Channels

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Abstract

There are many different calcium channels expressed in the mammalian nervous system, but N-type and P/Q-type calcium channels appear to dominate the presynaptic terminals of central and peripheral neurons. The neurotransmitter-induced modulation of these channels can result in alteration of synaptic transmission. This review highlights the mechanisms by which neurotransmitters affect the activity of N-type and P/Q-type calcium channels. The inhibition of these channels by voltage-dependent and voltage-independent mechanisms is emphasized because of the wealth of information available on the intracellular mediators and on the effect of these pathways on the single-channel gating.

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  1. Department of Physiology, Tulane University Health Science Center, New Orleans, Louisiana, 70112

    Keith S. Elmslie

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Elmslie, K.S. Neurotransmitter Modulation of Neuronal Calcium Channels. J Bioenerg Biomembr 35, 477–489 (2003). https://doi.org/10.1023/B:JOBB.0000008021.55853.18

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  • DOI: https://doi.org/10.1023/B:JOBB.0000008021.55853.18

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