Abstract
Previous studies have shown the possibility of developing in-situ polymerizable hydrogels that disclose a range of properties that might allow for their use as bone cements. Their main advantage is to be partially degradable, which is important to allow bone ingrowth (better fixation). In addition, their uptake of water makes them less agressive for the tissues, disclosing better fatigue properties and ideal for release of drugs when in service.This work reports a statistical study of the formulation of partially degradable acrylic bone cements that include on their composition corn starch/cellulose acetate blends (SCA). The aim was to optimize a set of properties (mechanical, swelling/degradation and curing) by changing the values of some parameters such as SCA amount and particle size and molar ratio of the acrylic monomers. Statistical tests demonstrated that the most important parameter was the molar ratio of monomers, with the SCA percentage also playing a role. It was possible to develop formulations with mechanical properties in the range of ASTM specifications and with polymerization temperatures lower than those of commercial acrylic cements. Some formulations were subsequently selected for tensile and dynamic mechanical thermal analysis (DMA) tests, under dry and wet conditions.
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S. Shinzato, T. Nakamura, T. Kokubo and Y. Kitamura, J. Biomed. Mater. Res. 59 (2002) 225.
E. J. Harper, M. Braden and W. J. Bonfield, J. Mater. Sci. Mater. Med. 11 (2000) 491.
S. Morita, K. Furuya, K. Ishihara and N. Nakabayashi, Biomaterials 19 (1998) 1601.
C. Elvira, B. Vaízquez, J. San Romaín, B. Levenfeld, P. Ginebra, X. Gil and J. A. Planell, J. Mater. Sci. Mater. Med. 9 (1998) 679.
M. E. Gomes, A. S. Ribeiro, P. B. Malafaya, R. L. Reis and A. M. Cunha, Biomaterials 22 (2001) 883.
M. E. Gomes, R. L. Reis, A. M. Cunha, C. A. Blitterswijk and J. D. De Bruijn, ibid. 22 (2001) 1911.
M. E. Gomes, J. S. Godinho, D. Tchalamov, A. M. Cunha and R. L. Reis, Mater. Sci. Eng. C 20 (2002) 19.
C. Elvira, J. F. Mano, J. San Romaín and R. L. Reis, Biomaterials 23 (2002) 1955.
P. B. Malafaya, C. Elvira, A. Gallardo, J. San Romaín and R. L. Reis, J. Biomater. Sci. Polym. Ed. 12 (2001) 1227.
R. A. Sousa, G. Kalay, R. L. Reis, A. M. Cunha and M. J. Bevis, J. Appl. Polym. Sci. 77 (2000) 1303.
R. L. Reis, A. M. Cunha and M. J. Bevis, Med. Plast. Biomater. 4 (1997) 46.
C. S. Pereira, A. M. Cunha, R. L. Reis, B. Vaízquez and J. San Romaín, J. Mater. Sci. Mater. Med. 9 (1998) 825.
I. Espigares, C. Elvira, J. F. Mano, B. Vaízquez, J. San Roman and R. L. Reis, Biomaterials 23 (2002) 1883.
D. C. Montgomery, “Design and Analysis of Experiments”, 3rd edn (John Wiley & Sons, Singapore, 1991).
G. E. P. Box, W. G. Hunter and J. S. Hunter, “Statistics for Experimenters” (John Wiley & Sons, New York, 1978).
J. Brandrup, E. H. Immergut and E. A. Grulke (eds), “Polymer Handbook”, 4th edn (Wiley Interscience, New York, 1999).
“Standard Specification for Acrylic Bone Cements. Annual Book of ASTM Standards, v.13.01, Specification F451-86” (ASTM, Philadelphia, 1986).
G. Lewis, J. Biomed. Mater. Res. 38 (1997) 155.
S. Turner, in “Encyclopedia of Materials Science and Technology” (Elsevier Science, Amsterdam, 2001).
J. D. Ferry, in “Viscoelastic Properties of Polymers”, 3rd edn (John Wiley & Sons, New York, 1980).
J. F. Mano, R. L. Reis and A. M. Cunha, in “Polymer Based Systems on Tissue Engineering, Replacement and Regeneration”, edited by R. L. REIS and D. COHN (Nato Science Series, Kluwer Academic, Dordrecht, 2002) pp. 139-164.
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Boesel, L.F., Mano, J.F. & Reis, R.L. Optimization of the formulation and mechanical properties of starch based partially degradable bone cements. Journal of Materials Science: Materials in Medicine 15, 73–83 (2004). https://doi.org/10.1023/B:JMSM.0000010100.07715.eb
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DOI: https://doi.org/10.1023/B:JMSM.0000010100.07715.eb