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H2O2-Induced Platelet Aggregation and Increase in Intracellular Ca2+ Concentration Are Blocked by Inhibitors of Intracellular Signaling

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Abstract

Inhibitors of signaling enzymes such as guanosine-5′-O-2-thiodiphosphate, aristolochic acid, aspirin, indomethacin, and trifluoperazine block H2O2-induced platelet aggregation and H2O2-induced increase in the intracellular concentration of Ca2+. These findings suggest that the effect of H2O2 on platelets is associated with activation of signal pathways responsible for increase in the concentration of intracellular Ca2+. On H2O2-induced platelet aggregation, the concentration of cAMP in the cytoplasm decreases and that of cGMP increases.

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Authors and Affiliations

  1. Department of Biophysics, Belarusian State University, pr. F. Skoriny 4, Minsk, 220050, Belarus

    E. N. Loiko & A. B. Samal

  2. National Academy of Sciences of Belarus, ul. Akad. Kuprevicha 5/2, Institute of Bioorganic Chemistry, Minsk, 220141, Belarus

    S. M. Shulyakovskaya

Authors
  1. E. N. Loiko
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  2. A. B. Samal
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  3. S. M. Shulyakovskaya
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Loiko, E.N., Samal, A.B. & Shulyakovskaya, S.M. H2O2-Induced Platelet Aggregation and Increase in Intracellular Ca2+ Concentration Are Blocked by Inhibitors of Intracellular Signaling. Biochemistry (Moscow) 68, 1210–1216 (2003). https://doi.org/10.1023/B:BIRY.0000009135.85883.65

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  • DOI: https://doi.org/10.1023/B:BIRY.0000009135.85883.65

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