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Secretory Activity of Mast Cell during Stress: Effect of Prolyl-Glycyl-Proline and Semax

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Abstract

Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    B. A. Umarova, G. N. Kopylova, E. A. Smirnova, A. A. Guseva & S. E. Zhuikova

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  1. B. A. Umarova
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  2. G. N. Kopylova
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  3. E. A. Smirnova
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  4. A. A. Guseva
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  5. S. E. Zhuikova
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Correspondence to E. A. Smirnova.

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Umarova, B.A., Kopylova, G.N., Smirnova, E.A. et al. Secretory Activity of Mast Cell during Stress: Effect of Prolyl-Glycyl-Proline and Semax. Bulletin of Experimental Biology and Medicine 136, 325–327 (2003). https://doi.org/10.1023/B:BEBM.0000010942.14275.50

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  • DOI: https://doi.org/10.1023/B:BEBM.0000010942.14275.50

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