Abstract
In a double-blind, crossover study, wedetermined whether microencapusulated pancreatic enzymesreduce postprandial symptoms experienced by healthyvolunteers after ingestion of a high calorie, high fat meal. At 7 AM, 18 subjects ingested 185 g ofcookies (1196 calories and 72 g of fat) with threepancrelipase capsules or a placebo. The severity ofgastrointestinal symptoms and flatus passages wererecorded for 15-17 hr, and end-alveolar samples wereobtained hourly for 10 hr. Ingestion of pancreaticsupplements was associated with a significant (P =0.049) reduction in bloating over the entire recordingperiod, and with significant reductions in bloating,gas, and fullness during the dinner to bedtime period.Pancreatic supplements had no significant effect onbreath H2 or CH4 concentration.The finding that pancreatic supplements reduce postprandial symptoms inhealthy subjects suggests that these supplements alsomight be beneficial in irritable bowelsyndrome.
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REFERENCES
Talley NJ, Phillips SF: Non-ulcer dyspepsia: potential causes and pathophysiology. Ann Intern Med 108:865–879, 1988
Drossman DA, Thompson WG: The irritable bowel syndrome: Review and a graduated multicomponent treatment approach. Ann Intern Med 116:1009–1016, 1992
Gullo L, Pezzilli R, Cassano A, Ligabue A, Ventrucci M, Barbara L: Clinical effectiveness of a new enteric-coated pancre atic enzyme extract in the treatme nt of pancreatic steatorrhea. Curr Ther Res 44:105–109, 1988
Kerlin P, Wong L, Harris B, Capra S: Rice flour, breath hydrogen and malabsorption. Gastroenterology 87:578–585, 1984
Anderson IH, Levine AS, Levitt MD: Incomplete absorption of the carbohydrate in all-purpose wheat flour. N Engl J Med 304:891–892, 1981
Strocchi A, Ellis CJ, Levitt MD: Reproducibility of measurements of trace gas concentrations in expired air. Gastroenterology 101:175–179, 1991
Sachs L: Applied Statistics: A Handbook of Techniques, 5th ed. Springer Verlag, New York, 1982
SYSTAT for the Macintosh, version 5.2, Evanston, Illinois, SYSTAT, 1992
Strocchi A, Corazza G, Ellis C, Gasbarrini G, Levitt MD: Detection of malabsorption of low dose s of carbohydrate-accuracy of various breath H2 criteria. Gastroenterology 105:1404–1410, 1993
Go VL, Hofmann AF, Summerskill WHJ: Pancre ozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. J Clin Invest 49:1558–1564, 1970
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Suarez, F., Levitt, M.D., Adshead, J. et al. Pancreatic Supplements Reduce Symptomatic Response of Healthy Subjects to a High Fat Meal. Dig Dis Sci 44, 1317–1321 (1999). https://doi.org/10.1023/A:1026675012864
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DOI: https://doi.org/10.1023/A:1026675012864